Clear Cell Adenocarcinoma Arising From Adenomyosis
Clear Cell Adenocarcinoma Arising From Adenomyosis
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DOI：
10.1097/pgp.0b013e31818e101f
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发表时间：
2009-05-01
影响因子：
2.4
通讯作者：
Osamura, Robert Yoshiyuki
中科院分区：
文献类型：
--
作者：
Hirabayashi, Kenichi;Yasuda, Masanori;Osamura, Robert Yoshiyuki
一位73岁的绝经后日本妇女主诉轻微发烧和体重减轻。血中CA125水平升高有利于恶性子宫体肿瘤的诊断，但未经子宫内膜细胞学和活检证实。子宫切除发现子宫肌层内有白色实性肿瘤，诊断为子宫腺肌病所致的透明细胞腺癌。子宫腺肌症、非侵袭性CCA的子宫内膜上皮之间有过渡。和侵入性的CCA。肝细胞核因子-1β的免疫组织化学表达支持CCA的诊断。目前只有一份关于子宫腺肌病引起的CCA的英文文献。当血清CA125等肿瘤标志物水平较高，且肿瘤位于子宫肌内时，子宫腺肌病所致的恶性肿瘤应作为鉴别诊断。
A 73-year-old postmenopausal Japanese woman presented with a complaint of slight fever and weight loss. An elevated level of CA 125 in the blood favored a diagnosis of malignant uterine body tumor, but was not confirmed by endometrial cytology and biopsy. Resection of the uterus revealed a solid whitish tumor in the myometrium that was diagnosed as clear cell adenocarcinoma (CCA) arising from adenomyosis. There were transitions between endometrial epithelium of adenomyosis, noninvasive CCA. and invasive CCA. Immunohistochemical expression of hepatocyte nuclear factor-1 beta supported the diagnosis of CCA. Only one other English language document pertaining to CCA arising from adenomyosis exists. Malignant tumor arising from adenomyosis should be considered as a differential diagnosis when the serum level of tumor markers such as CA125 is high and when the tumor is intramyometrial.