Place-learning, but not cue-learning training, modifies the hippocampal theta rhythm in rats
Place-learning, but not cue-learning training, modifies the hippocampal theta rhythm in rats
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DOI：
10.1016/s0361-9230(02)00769-4
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发表时间：
2002-07-01
影响因子：
3.8
通讯作者：
González-Burgos, I
中科院分区：
文献类型：
--
作者：
Olvera-Cortés, E;Cervantes, M;González-Burgos, I
大鼠的海马theta活动伴随着跑步、游泳、头部运动和空间定向反应等行为。然而，这一活动与信息处理之间是否存在关系尚不清楚。由于位置学习依赖于海马体的完整性，而线索学习不依赖于此，因此对每个测试背后的海马theta活动进行了评估。在Morris迷宫中记录1组大鼠(n=10)和1组线索学习组(n=8)连续6天的CA1区局部脑电。在清醒不动、搜索和站台阶段进行相应测试的脑电检查。将脑电的相对功率(Rp)值分为4~6.5 Hz、6.5~9.5 Hz和9.5~12 Hz三个频段。位置学习训练在搜索阶段和平台阶段产生了4-6.5赫兹和6.5-9.5赫兹两个亚带的分离，在搜索过程中6.5-9.5赫兹亚带上的活动高于基础记录，而线索学习组在训练阶段和行为阶段都没有表现出差异。由于两组的运动活动和游泳速度相似，结果强烈表明，在theta活动中观察到的变化反映了海马体的信息处理。(C)2002 Elsevier Science Inc.保留所有权利。
Hippocampal theta activity accompanies behaviours such as running, swimming, head movements and spatially orientated responses in the rat. However, whether a relationship between this activity and information processing exists remains unclear. As place-learning depends on hippocampal integrity, whereas cue-learning does not, the hippocampal theta activity underlying each test was evaluated. Local CA1 hippocampal electroencephalograms (EEGs) were recorded over 6 days in a Morris maze for one place-learning test group of rats (n = 10) and one cue-learning test group (n = 8). The EEG of the corresponding test was taken during waking immobile, searching, and on-platform stages. The relative power (RP) values of EEGs were divided into 4-6.5 Hz, 6.5-9.5 Hz, and 9.5-12 Hz frequency sub-bands. The place-learning training produced a separation of 4-6.5 Hz and 6.5-9.5Hz sub-bands in searching and platform stages and a higher activity on the 6.5-9.5Hz sub-band during searching, compared with the basal record, while the cue-learning group did not show differences related either to the training or behavioural stage. As the motor activity and swimming velocity was similar in both groups, the results strongly suggest that the changes observed in theta activity reflect information processing by the hippocampus. (C) 2002 Elsevier Science Inc. All rights reserved.