Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors.
Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors.
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DOI：
10.1016/s1388-1981(02)00141-5
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发表时间：
2002-05
期刊：
影响因子：
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通讯作者：
J. V. Van Brocklyn;B. Behbahani;N. H. Lee
中科院分区：
文献类型：
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作者：
J. V. Van Brocklyn;B. Behbahani;N. H. Lee
鞘氨醇-1-磷酸(S1P)与一组被称为S1P/EDG家族的G蛋白偶联受体(GPCRs)的几个成员结合并通过其传递信号。这些受体中的几个在不同类型的细胞中共表达，最近的报道表明，S1P的生物学效应通常需要不止一个S1P受体亚型。最近的证据表明，许多GPCR以二聚体的形式存在。我们发现S1P受体与S1P受体亚家族的其他成员形成同源二聚体和异源二聚体。我们还讨论了GPCR二聚体在受体功能中所起的作用，以及这对S1P信号的可能意义。
Sphingosine-1-phosphate (S1P) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1P/EDG family. Several of these receptors are coexpressed in various cell types and recent reports have shown that biological effects of S1P often require more than one S1P receptor subtype. Recent evidence indicates that many GPCRs exist as dimers. We show that S1P receptors form both homodimers as well as heterodimers with other members of the S1P subfamily of receptors. We also discuss the role that GPCR dimers play in receptor function and what this may mean for S1P signaling.