Cognitive deficits in people who have recovered from COVID-19.
Cognitive deficits in people who have recovered from COVID-19.
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DOI：
10.1016/j.eclinm.2021.101044
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发表时间：
2021-09
影响因子：
15.1
通讯作者：
Mehta MA
中科院分区：
文献类型：
--
作者：
Hampshire A;Trender W;Chamberlain SR;Jolly AE;Grant JE;Patrick F;Mazibuko N;Williams SC;Barnby JM;Hellyer P;Mehta MA
人们越来越担心COVID-19可能造成的认知后果，有报道称，“长期COVID”症状持续到慢性期，病例研究显示，严重受影响的患者存在神经系统问题。然而，关于感染后或整个疾病严重程度的全面传播中认知问题的性质和更广泛的患病率的信息很少。我们试图确认来自81，337名参与者的横断面认知表现数据与问卷项目之间是否存在关联，这些参与者在2020年1月至12月期间进行了临床验证的网络优化评估，作为大不列颠智力测试的一部分，这些问卷项目收集了疑似和确诊的COVID-19感染和呼吸道症状的自我报告。从COVID-19中康复的人，包括那些不再报告症状的人，在控制年龄、性别、教育水平、收入、种族-民族、先前存在的医学疾病、疲劳、抑郁和焦虑时，与对照组相比表现出显著的认知缺陷。对于已住院患者（N = 192），以及生物学确认COVID-19感染的未住院病例（N = 326），这些缺陷具有显著的效应量。分析发病前智力的标志物并不支持这些差异在感染前存在。对子测试的性能进行更精细的分析支持了COVID-19对人类认知产生多领域影响的假设。口译。这些结果雅阁了“长期新冠肺炎”认知症状持续到早期慢性阶段的报道。他们应该作为一个号角，进一步研究与纵向和神经成像队列绘制恢复轨迹，并确定SARS-COV-2幸存者认知缺陷的生物学基础。经费AH得到了英国痴呆症研究所护理研究和技术中心以及伦敦帝国理工学院生物医学研究中心的支持。WT由EPSRC神经技术博士培训中心支持。SRC由Wellcome Trust Clinical Fellowship 110，049/Z/15/Z资助。JMB由医学研究理事会（MR/N 013700/1）支持。MAM、SCRW和PJH部分得到了位于南伦敦的国家健康研究所（NIHR）生物医学研究中心、Maudsley NHS基金会信托基金和伦敦国王学院的支持
There is growing concern about possible cognitive consequences of COVID-19, with reports of ‘Long COVID’ symptoms persisting into the chronic phase and case studies revealing neurological problems in severely affected patients. However, there is little information regarding the nature and broader prevalence of cognitive problems post-infection or across the full spread of disease severity. We sought to confirm whether there was an association between cross-sectional cognitive performance data from 81,337 participants who between January and December 2020 undertook a clinically validated web-optimized assessment as part of the Great British Intelligence Test, and questionnaire items capturing self-report of suspected and confirmed COVID-19 infection and respiratory symptoms. People who had recovered from COVID-19, including those no longer reporting symptoms, exhibited significant cognitive deficits versus controls when controlling for age, gender, education level, income, racial-ethnic group, pre-existing medical disorders, tiredness, depression and anxiety. The deficits were of substantial effect size for people who had been hospitalised (N = 192), but also for non-hospitalised cases who had biological confirmation of COVID-19 infection (N = 326). Analysing markers of premorbid intelligence did not support these differences being present prior to infection. Finer grained analysis of performance across sub-tests supported the hypothesis that COVID-19 has a multi-domain impact on human cognition. Interpretation. These results accord with reports of ‘Long Covid’ cognitive symptoms that persist into the early-chronic phase. They should act as a clarion call for further research with longitudinal and neuroimaging cohorts to plot recovery trajectories and identify the biological basis of cognitive deficits in SARS-COV-2 survivors. Funding. AH is supported by the UK Dementia Research Institute Care Research and Technology Centre and Biomedical Research Centre at Imperial College London. WT is supported by the EPSRC Centre for Doctoral Training in Neurotechnology. SRC is funded by a Wellcome Trust Clinical Fellowship 110,049/Z/15/Z. JMB is supported by Medical Research Council (MR/N013700/1). MAM, SCRW and PJH are, in part, supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
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影响因子：
9.9
作者：
McGurn, B;Starr, JM;Deary, IJ
通讯作者：
Deary, IJ
影响因子：
14.5
作者：
Jolly, Amy E.;Scott, Gregory T.;Hampshire, Adam H.
通讯作者：
Hampshire, Adam H.
影响因子：
16.6
作者：
Soreq E;Violante IR;Daws RE;Hampshire A
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Hampshire A
影响因子：
64.3
作者：
Holmes, Emily A.;O'Connor, Rory C.;Bullmore, Ed
通讯作者：
Bullmore, Ed
影响因子：
5.4
作者：
Chamberlain SR;Grant JE;Trender W;Hellyer P;Hampshire A
通讯作者：
Hampshire A