Interleukin-1 Beta-A Friend or Foe in Malignancies?
Interleukin-1 Beta-A Friend or Foe in Malignancies?
复制标题
DOI：
10.3390/ijms19082155
复制
发表时间：
2018-07-24
影响因子：
5.6
通讯作者：
Bros M
中科院分区：
文献类型：
--
作者：
Bent R;Moll L;Grabbe S;Bros M
白细胞介素-1 β（IL-1β）由多种免疫细胞类型中的炎症信号诱导。IL-1β（和IL-18）是炎性小体介导的活化后由caspase-1加工的唯一细胞因子。本文综述了IL-1β表达调控参数及其在病理生理条件下的多方面作用。IL-1信号传导激活包括抗原呈递细胞在内的先天性免疫细胞，并驱动CD 4 + T细胞向辅助性T细胞（Th）1和Th 17细胞极化。因此，IL-1β在缓解急性炎症和启动适应性抗肿瘤反应方面具有很大的有益作用。然而，在慢性炎症过程中产生的IL-1β支持肿瘤的发展。此外，主要由肿瘤浸润性巨噬细胞在肿瘤微环境内产生的IL-1β通过不同的机制促进肿瘤生长和转移。这些包括促进新血管生成的IL-1靶标的表达和在肿瘤细胞中引起抗凋亡信号的癌症相关成纤维细胞中的可溶性介质的表达。此外，IL-1促进骨髓源性抑制细胞的增殖。使用遗传小鼠模型以及用于药理学抑制IL-1信号传导的药物治疗性地应用于治疗IL-1相关自身免疫性疾病表明IL-1β是肿瘤诱导和发展的驱动因素。
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4+ T cells towards T helper type (Th) 1 and Th17 cells. Therefore, IL-1β has been attributed a largely beneficial role in resolving acute inflammations, and by initiating adaptive anti-tumor responses. However, IL-1β generated in the course of chronic inflammation supports tumor development. Furthermore, IL-1β generated within the tumor microenvironment predominantly by tumor-infiltrating macrophages promotes tumor growth and metastasis via different mechanisms. These include the expression of IL-1 targets which promote neoangiogenesis and of soluble mediators in cancer-associated fibroblasts that evoke antiapoptotic signaling in tumor cells. Moreover, IL-1 promotes the propagation of myeloid-derived suppressor cells. Using genetic mouse models as well as agents for pharmacological inhibition of IL-1 signaling therapeutically applied for treatment of IL-1 associated autoimmune diseases indicate that IL-1β is a driver of tumor induction and development.
登录
查看更多内容
影响因子：
4
作者：
Aylon, Yael;Oren, Moshe
通讯作者：
Oren, Moshe
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
30.5
作者：
Baroja-Mazo, Alberto;Martin-Sanchez, Fatima;Pelegrin, Pablo
通讯作者：
Pelegrin, Pablo
DOI：
10.1084/jem.20100050
发表时间：
2010-05-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen IC;TeKippe EM;Woodford RM;Uronis JM;Holl EK;Rogers AB;Herfarth HH;Jobin C;Ting JP
通讯作者：
Ting JP
影响因子：
6.1
作者：
Bellehumeur, C.;Blanchet, J.;Akoum, A.
通讯作者：
Akoum, A.