Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34 T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering
Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34 T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering
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DOI：
10.1016/j.bandl.2017.09.004
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发表时间：
2017-12-01
影响因子：
2.5
通讯作者：
Mehrpour, Masoud
中科院分区：
文献类型：
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作者：
Mohammadi, Hiwa;Joghataei, Mohammad Taghi;Mehrpour, Masoud
发育性口吃是一种性别二态性和男性偏好的言语运动控制障碍。在本病例对照研究中，我们调查了发展性口吃和类固醇激素之间的关系。比较口吃儿童（CWS）和非口吃儿童（CWNS）的血清睾酮、双氢睾酮（DHT）、脱氢表雄酮（DHEA）、雌二醇、孕酮、皮质醇和性激素结合球蛋白（SHBG）水平以及产前睾酮水平的指标第2/4指比（2D：4D）。此外，两个SNP（CYP 17 -34 T：C（MSP AI）和CYP 19 T：C（Trp：Arg））的细胞色素P450，这是参与类固醇代谢途径，分析组之间。我们的研究结果表明，显着较高的水平，睾酮，双氢睾酮，雌二醇在CWS与CWNS相比。口吃的严重程度与血清睾酮、脱氢表雄酮和皮质醇水平呈正相关，而口吃与指数比、孕酮或SHBG之间没有相关性。CYP 17 CC基因型与该疾病显著相关。
Developmental stuttering is known to be a sexually dimorphic and male-biased speech motor control disorder. In the present case-control study, we investigated the relationship between developmental stuttering and steroid hormones. Serum levels of testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), oestradiol, progesterone, cortisol, and sex hormone binding globulin (SHBG), as well as the 2nd/4th digit ratio (2D:4D), an indicator of prenatal testosterone level, were compared between children who stutter (CWS) and children who do not stutter (CWNS). Moreover, two SNPs (CYP17-34 T:C (MSP AI) and CYP19 T:C (Trp:Arg)) of cytochrome P450, which is involved in steroid metabolism pathways, were analysed between the groups. Our results showed significantly higher levels of testosterone, DHT, and oestradiol in CWS in comparison with CWNS. The severity of stuttering was positively correlated with the serum levels of testosterone, DHEA, and cortisol, whereas no association was seen between the stuttering and digit ratio, progesterone, or SHBG. The CYP17CC genotype was significantly associated with the disorder.