Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine
Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine
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DOI：
10.1002/agt2.120
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Yangmeihui Song;Wenyu Song;X. Lan;W. Cai;Dawei Jiang
中科院分区：
文献类型：
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作者：
Yangmeihui Song;Wenyu Song;X. Lan;W. Cai;Dawei Jiang
球形核酸（SNA）由纳米颗粒核心和一层密集排列的寡核苷酸壳组成。 Mirkin 及其同事于 1996 年首次报告 SNA 后，它为基因和药物输送领域提供了新的可能性，引起了人们的极大兴趣。寡核苷酸在有机/无机纳米粒子表面上的受控聚集改善了基因和核酸药物的递送，并改变和调节生物体内纳米粒子核心的生物特征。在这篇综述中，我们概述了 SNA 的最新进展，这些进展加速了其生物医学应用及其向临床应用的潜在转变。我们首先介绍 SNA 作为药物/基因传递系统的概念和特点，并重点介绍最近通过成像和治疗各种疾病进行生物工程 SNA 的努力。最后，我们讨论了 SNA 的潜在挑战和机遇、正在进行的临床试验和未来的转化，以及它们如何影响当前的临床实践格局。我们希望这篇综述能够更新我们目前对 SNA（有组织的寡核苷酸聚集体）用于疾病诊断和治疗的理解。
Spherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by Mirkin and coworkers in 1996, it has created a significant interest by offering new possibilities in the field of gene and drug delivery. The controlled aggregation of oligonucleotides on the surface of organic/inorganic nanoparticles improves the delivery of genes and nucleic acid–based drugs and alters and regulates the biological profiles of the nanoparticle core within living organisms. Here in this review, we present an overview of the recent progress of SNAs that has speeded up their biomedical application and their potential transition to clinical use. We start with introducing the concept and characteristics of SNAs as drug/gene delivery systems and highlight recent efforts of bioengineering SNA by imaging and treatmenting various diseases. Finally, we discuss potential challenges and opportunities of SNAs, their ongoing clinical trials, and future translation, and how they may affect the current landscape of clinical practices. We hope that this review will update our current understanding of SNA, organized oligonucleotide aggregates, for disease diagnosis and treatment.