Extrinsic and intrinsic determinants of nerve regeneration.
Extrinsic and intrinsic determinants of nerve regeneration.
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DOI：
10.1177/2041731411418392
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发表时间：
2011
影响因子：
8.2
通讯作者：
Son YJ
中科院分区：
文献类型：
--
作者：
Ferguson TA;Son YJ
在中枢神经系统（CNS）损伤后，轴突不能再生，通常导致持续的神经功能缺损，尽管受损的外周神经系统（PNS）轴突产生可导致功能恢复的强有力的再生反应。CNS再生的一些失败是由于在受损CNS中发现的许多基于神经胶质的抑制性分子引起的，而一些CNS神经元的固有再生潜力在CNS成熟期间被主动削减，并且在损伤后受到限制。在这篇综述中，神经系统内轴突再生的外在和内在调制的分子基础进行了评估。更全面地了解轴突再生的限制因素将为神经系统损伤的治疗提供合理的依据。
After central nervous system (CNS) injury axons fail to regenerate often leading to persistent neurologic deficit although injured peripheral nervous system (PNS) axons mount a robust regenerative response that may lead to functional recovery. Some of the failures of CNS regeneration arise from the many glial-based inhibitory molecules found in the injured CNS, whereas the intrinsic regenerative potential of some CNS neurons is actively curtailed during CNS maturation and limited after injury. In this review, the molecular basis for extrinsic and intrinsic modulation of axon regeneration within the nervous system is evaluated. A more complete understanding of the factors limiting axonal regeneration will provide a rational basis, which is used to develop improved treatments for nervous system injury.