Anatomy of a Hotspot: Chain and Seroepidemiology of Ebola Virus Transmission, Sukudu, Sierra Leone, 2015-16
Anatomy of a Hotspot: Chain and Seroepidemiology of Ebola Virus Transmission, Sukudu, Sierra Leone, 2015-16
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DOI：
10.1093/infdis/jiy004
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发表时间：
2018-04-15
影响因子：
6.4
通讯作者：
Richardson, Eugene T.
中科院分区：
文献类型：
--
作者：
Kelly, J. Daniel;Barrie, Mohamed Bailor;Richardson, Eugene T.
研究尚未包括埃博拉相关传播链中的最低症状埃博拉病毒（EBOV）感染和未识别的埃博拉病毒病（EVD）以及流行病学风险估计。2015年10月至2016年1月，我们在塞拉利昂Sukudu村埃博拉疫情爆发期间，对2014年11月至2015年2月居住在隔离家庭的221名个人进行了一项横断面血清流行病学调查。在48例EBOV感染者中，25%（95%置信区间[CI]，14%-40%）有轻微症状的EBOV感染，4%（95% CI，1%-14%）为未识别的EVD病例。在传播链中，最小症状的EBOV感染模式是非随机的（P <0.001，排列检验）。没有与EVD病例住在同一所房子里与最小症状感染显著相关。这是第一个研究EBOV传播链的研究，包括最小症状的EBOV感染和未识别的EVD。我们的发现为埃博拉病毒传播动力学和检疫措施提供了新的见解。
Studies have yet to include minimally symptomatic Ebola virus (EBOV) infections and unrecognized Ebola virus disease (EVD) in Ebola-related transmission chains and epidemiologic risk estimates. We conducted a cross-sectional, sero-epidemiological survey from October 2015 to January 2016 among 221 individuals living in quarantined households from November 2014 to February 2015 during the Ebola outbreak in the village of Sukudu, Sierra Leone. Of 48 EBOV-infected persons, 25% (95% confidence interval [Cl], 14%-40%) had minimally symptomatic EBOV infections and 4% (95% CI, 1%-14%) were unrecognized EVD cases. The pattern of minimally symptomatic EBOV infections in the transmission chain was nonrandom (P < .001, permutation test). Not having lived in the same house as an EVD case was significantly associated with minimally symptomatic infection. This is the first study to investigate a chain of EBOV transmission inclusive of minimally symptomatic EBOV infections and unrecognized EVD. Our findings provide new insights into Ebola transmission dynamics and quarantine practices.