PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
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DOI：
10.1038/bjc.1997.513
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发表时间：
1997
影响因子：
8.8
通讯作者：
Gallagher JA
中科院分区：
文献类型：
--
作者：
Carron JA;Fraser WD;Gallagher JA
使用从手术中取出的人类肿瘤样本中提取的RNA，我们分析了一组人类乳腺和结肠肿瘤中甲状旁腺激素相关蛋白（PTHrP）和PTH/PTHrP受体的mRNA表达。18个乳腺肿瘤样本中除1个外均表达PTHrP，而其中11个样本中检测到受体表达。PTH/PTHrP受体的表达被发现在三个转移性病变，包括一个样本中，没有受体在原发性肿瘤检测。PTHrP的表达也在5个结肠肿瘤中检测到，其中两个检测到受体表达。这些结果表明，PTHrP和PTHrP受体也共同表达在乳腺肿瘤在体内，并提供进一步的证据表明，PTHrP可能是一个重要的自分泌/旁分泌生长因子在乳腺癌。
Using RNA extracted from human tumour samples removed during surgery, we have analysed expression of mRNA for parathyroid hormone-related protein (PTHrP) and for the PTH/PTHrP receptor by RT-PCR in a panel of human breast and colon tumours. All but 1 of 18 breast tumour samples expressed PTHrP, whereas receptor expression was detected in 11 of these. Expression of the PTH/PTHrP receptor was found in three out of four metastatic lesions, including one sample in which no receptor was detected in the primary tumour. PTHrP expression was also detected in five colon tumours, and receptor expression detected in two of these. These results demonstrate that PTHrP and the PTHrP receptor are also co-expressed in breast tumours in vivo and provide further evidence that PTHrP may be an important autocrine/paracrine growth factor in breast cancer.