Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COP
Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COP
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DOI：
10.1183/09031936.00040307
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发表时间：
2008-07-01
影响因子：
24.3
通讯作者：
Sandford, A. J.
中科院分区：
文献类型：
--
作者：
He, J-Q.;Shumansky, K.;Sandford, A. J.
粒细胞-巨噬细胞集落刺激因子（CSF），也称为CSF 2，和粒细胞CSF，也称为CSF 3，是中性粒细胞和巨噬细胞的重要存活和增殖因子。本研究的目的是确定CSF 2和CSF 3的单核苷酸多态性（SNP）是否与吸烟诱导的慢性阻塞性肺疾病的肺功能相关。在587名非西班牙裔白色受试者中研究了CSF 2和CSF 3的5个SNP，其中最快的（n=281）或最慢的（n=306）在国家心肺血液研究所肺健康研究（LHS）中，从连续吸烟者中选择肺功能下降。这些SNPs也在1,074名非西班牙裔白色受试者中进行了研究，这些受试者在LHS开始时具有最低（n=536）或最高（n=538）基线肺功能。CSF 3 - 1719 T等位基因数量的增加与防止低肺功能显著相关（比值比0.7.3，95%置信区间0.56-0.95），调整多重比较后仍显着。CSF 3单倍型与一秒用力呼气量的基线水平也有显著相关性。没有发现CSF 2单核苷酸多态性和肺功能的关联，也没有上位性的证据。总之，集落刺激因子3的遗传变异与吸烟者的横截面测量肺功能相关。
Granulocyte-macrophage colony-stimulating factor (CSF), also known as CSF2, and granulocyte CSF, also known as CSF3, are important survival and proliferation factors for neutrophils and macrophages. The objective of the present study was to determine whether single nucleotide polymorphisms (SNPs) of CSF2 and CSF3 are associated with lung function in smoking-induced chronic obstructive pulmonary disease.In total, five SNPs of CSF2 and CSF3 were studied in 587 non-Hispanic white subjects with the fastest (n=281) or the slowest (n=306) decline of lung function selected from among continuous smokers in the National Heart, Lung, and Blood Institute Lung Health Study (LHS). These SNPs were also studied in 1,074 non-Hispanic white subjects with the lowest (n=536) or the highest (n=538) baseline lung function at the beginning of the LHS.An increase in the number of CSF3 -1719T alleles was significantly associated with protection against low lung function (odds ratio 0.7.3, 95% confidence interval 0.56-0.95), and was still significant after adjustment for multiple comparisons. There was also a significant association of a CSF3 haplotype with baseline levels of forced expiratory volume in one second. No association was found for CSF2 SNPs and lung function, nor was there evidence of epistasis.In conclusion, genetic variation in colony-stimulating factor 3 is associated with cross-sectionally measured lung function in smokers.