Biochemical observations in functioning human thyroid adenomas.
Biochemical observations in functioning human thyroid adenomas.
复制标题
功能性人类甲状腺腺瘤的生化观察。
DOI：
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发表时间：
1973
影响因子：
5.8
通讯作者：
J. Field
中科院分区：
文献类型：
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作者：
P. Larsen;K. Yamashita;A. Dekker;J. Field
在体内用TSH检测后，对两个功能性人甲状腺腺瘤组织进行了体外研究。第一位患者的腺瘤似乎集中了体内的TcO4−，并对TSH有反应，131I的摄取增加，尽管患者没有甲状腺功能亢进。第二例患者甲状腺功能亢进，外源性TSH注射导致血清T3明显升高。在体外实验中，第一个腺瘤组织没有捕获碘，尽管其碘含量至少是周围正常组织样本或其他5项正常人甲状腺研究中碘含量的6倍。然而，尽管新合成的MIT和DIT数量异常，但形成的T4数量却很少。腺瘤中T3和T4合成减少的进一步证据是通过免疫分析法检测腺瘤中蛋白酶水解物中T3和T4含量的减少。腺瘤组织中T4和T3水平分别为3.8和0.66 μg/g wet wt。
Tissue from two functioning human thyroid adenomas was studied in vitro after testing with TSH in vivo. The adenoma of the first patient appeared to concentrate TcO4− in vivo and responded to TSH with an increase in 131I uptake though the patient was not hyperthyroid. The second patient was hyperthyroid and exogenous TSH injection caused a significant increase in serum T3. In vitro, the tissue from the first adenoma did not trap iodide although the quantity of iodine organified was at least 6-fold greater than that found with either samples of the surrounding normal tissue or in 5 other studies of normal human thyroid. However, despite supranormal amounts of newly synthesized MIT and DIT, the quantity of T4 formed was quite small. Further evidence of decreased T3 and T4 synthesis in the adenoma was found in the decreased T3 and T4 content of the pronase hydrolysate of the adenoma as measured by immunoassay. T4 and T3 levels in the adenoma wore 3.8 and 0.66 μg/g wet wt, respectively, contrasted with levels...