LESIONS IN THE MEDIAL POSTERIOR REGION OF THE BST IMPAIR SEXUAL-BEHAVIOR IN SEXUALLY EXPERIENCED AND INEXPERIENCED MALE-RATS
LESIONS IN THE MEDIAL POSTERIOR REGION OF THE BST IMPAIR SEXUAL-BEHAVIOR IN SEXUALLY EXPERIENCED AND INEXPERIENCED MALE-RATS
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DOI：
10.1016/0361-9230(94)00118-k
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发表时间：
1995-01-01
影响因子：
3.8
通讯作者：
DELABRIL, A
中科院分区：
文献类型：
--
作者：
CLARO, F;SEGOVIA, S;DELABRIL, A
以往的研究表明，经验丰富的雄性大鼠终纹床核的损伤会损害性行为的某些参数。本研究的目的是研究终纹床核（BSTMP）内侧后区对雄性大鼠性行为调节的贡献。BSTMP是尾纹床核的一个两性二态区域，与马鼻系统有关。在有经验和没有经验的雄性异性恋大鼠的BSTMP中制造了小的双侧电解损伤。假性损伤的动物也被测试作为普通外科手术的控制效果。然后进行行为测试以获得男性性行为的标准测量。我们的研究结果表明，有性经验的雄性大鼠BSTMPs病变表现出增加的数量和插入的数量，因此，射精潜伏期。相比之下，性幼稚的雄性大鼠表现出首次进入潜伏期和射精潜伏期的增加，但后者是由于射精间隔时间的增加而发生的。这组研究还表明，雌性肛门生殖器区域的嗅觉调查与交配行为的开始和维持之间的相关性很低。结果表明，在实验室测试的人工条件下获得的性经验可以提供BSTMP在感觉整合过程中提供的一些线索，我们假设BSTMP调节了交配的开始和节奏。然而，在BSTMP中，性经验显然不提供任何其他类型的线索，这些线索提供或处理涉及调节插入和射精的引发。
Previous studies have showed that lesions in the bed nucleus of the stria terminalis of experienced male rats impair some parameters of sexual behavior. The aim of this study was to examine the contribution of the medial posterior region of the bed nucleus of the stria terminalis (BSTMP), a sexually dimorphic region of this nucleus that pertains to the vomeronasal system, to the modulation of sexual behavior of the male rat. Small electrolytic bilateral lesions in the BSTMP were made in male heterosexual experienced and inexperienced rats. Sham lesioned animals were also tested as a control of the effects of the general surgical procedures. Behavioral tests were then performed to obtain standard measures of masculine sexual behavior. Our results indicate that the sexually experienced male rats with lesioned BSTMPs showed increases in the number of mounts and the number of intromissions and, consequently, in ejaculation latency. In contrast, the sexually naive male rats showed increases in first mount and intromission latencies and in ejaculation latency, but the latter occurred due to increases in the interintromission intervals. This group also showed low correlations between olfactory investigation of the anogenital area of the female and initiation and maintenance of copulatory behavior. The results suggest that sexual experience obtained in the very artificial conditions of laboratory tests could supply some of the cues provided by the BSTMP in the process of sensorial integration, which we hypothesize modulates the initiation and pacing of copulation. However, sexual experience does not apparently supply any other kinds of cues provided or processed in the BSTMP that are involved in modulating the elicitation of intromissions and ejaculations.