CHLORDIAZEPOXIDE DIRECTLY ENHANCES POSITIVE INGESTIVE REACTIONS IN RATS
CHLORDIAZEPOXIDE DIRECTLY ENHANCES POSITIVE INGESTIVE REACTIONS IN RATS
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DOI：
10.1016/0091-3057(86)90341-2
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发表时间：
1986-02-01
影响因子：
3.6
通讯作者：
TREIT, D
中科院分区：
文献类型：
--
作者：
BERRIDGE, KC;TREIT, D
苯并二氮杂卓类药物，如利血平（CDP），可以促进许多物种的进食。这种效应一般被解释为苯二氮卓类抗焦虑作用的间接结果，尽管有些人质疑它是否反映了对食物强化特性的直接作用。本研究采用的行为措施，可以区分这些可能性：适口性依赖的消费行为引起的大鼠的口味。结果表明，利达环氧化物选择性地增强了口味的正面适口性，而对负面适口性影响很小或没有影响。净效应是使CDP给药后的味道更加强化。
Benzodiazepines such as chlordiazepoxide (CDP) promote feeding in a number of species. This effect has been interpreted generally to be an indirect consequence of benzodiazepine antianxiety action, although some have questioned whether it might not reflect instead a direct action upon the reinforcing properties of foods. The present study employed a behavioral measure that can discriminate between these possibilities: palatability-dependent consummatory actions elicited in rats by tastes. The results suggest that chloridazepoxide enhances the positive palatability of tastes selectively while having little or no effect on aversive palatibility. The net effect is to make tastes more reinforcing following CDP administration.