Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model Omega-3 fatty acids prevent liver neoplasia
Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model Omega-3 fatty acids prevent liver neoplasia
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DOI：
10.1016/j.bbalip.2010.06.008
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发表时间：
2010-10-01
影响因子：
4.8
通讯作者：
Towner, R. A.
中科院分区：
文献类型：
--
作者：
Griffitts, J.;Saunders, D.;Towner, R. A.
我们研究了非哺乳动物omega-3去饱和酶在小鼠肝癌发生模型中的作用。在c-myc和TGF-α（转化生长因子-α）中含有双重突变（DM）的小鼠（导致肝脏肿瘤）与含有ω-3去饱和酶的小鼠杂交。三重突变（TM）小鼠的MRI分析显示，在研究中92%的小鼠在所有时间点都没有瘤形成。TM（TGF α/c-myc/fat-1）小鼠肝组织的病理变化与对照小鼠肝组织相似。磁共振波谱（MRS）测量不饱和脂肪酸发现有显着差异（p
We investigated the effect of a non-mammalian omega-3 desaturase in a mouse hepatocarcinogenesis model. Mice containing double mutations (DM) in c-myc and TGF-alpha (transforming growth factor-a), leading to liver neoplasia, were crossed with mice containing omega-3 desaturase. MRI analysis of triple mutant (TM) mice showed the absence of neoplasia at all time points for 92% of mice in the study. Pathological changes of TM (TGF alpha/c-myc/fat-1) mouse liver tissue was similar to control mouse liver tissue. Magnetic resonance spectroscopy (MRS) measurements of unsaturated fatty acids found a significant difference (p