Tick subolesin is an ortholog of the akirins described in insects and vertebrates
Tick subolesin is an ortholog of the akirins described in insects and vertebrates
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DOI：
10.1016/j.dci.2008.11.002
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
de la Fuente, Jose
中科院分区：
文献类型：
--
作者：
Galindo, Ruth C.;Doncel-Perez, Ernesto;de la Fuente, Jose
蜱保护性抗原subolesin是一种参与控制多种细胞途径的调节蛋白。Subolesin在无脊椎动物和脊椎动物中是进化保守的，与alkirin具有序列同源性，alkirin是最近重新命名的一组蛋白质，被认为在果蝇和小鼠中起转录因子的作用。本研究的目的是提供证据的序列和功能之间的同源性蜱subolesin和akirins。系统发育分析表明，它们在进化上是保守的。分别在成年蜱和小鼠中比较了subolesin和akirin 2敲低的效果。结果表明，蜱subolesin是昆虫和脊椎动物akirins的直系同源物，并表明这些蛋白质在调节NF-κ B依赖和独立的信号转导和先天免疫应答基因的表达中起作用。这些结果表明，这些蛋白质在宿主-病原体相互作用中具有重要作用。(C)2008爱思唯尔有限公司保留所有权利。
The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to alkirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kappa B-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host-pathogen interactions. (C) 2008 Elsevier Ltd. All rights reserved.