[Evaluation of pancreatic oncofetal antigen (POA) in the diagnosis of pancreatic cancer].
[Evaluation of pancreatic oncofetal antigen (POA) in the diagnosis of pancreatic cancer].
复制标题
胰腺癌胎儿抗原（POA）评估在胰腺癌诊断中的应用[J].
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
K. Nishida
中科院分区：
文献类型：
--
作者：
K. Nishida
胰腺癌胚抗原（POA）被认为是人类胰腺的癌胚抗原，其测定似乎有助于胰腺癌的诊断。本文对胰腺癌、慢性胰腺炎及其它疾病患者血清、胰液中POA、CEA、铁蛋白、β 2微球蛋白（BMG）、AFP进行了检测，并对其诊断价值进行了比较评价。POA对胰腺癌的敏感性最高，其次为CEA等。胰液中POA和CEA的敏感性和特异性均高于血清，可能反映早期恶性状态。应用免疫组化方法观察了胰腺癌及胎儿胰腺组织中POA的定位。在某些血清CEA、铁蛋白和BMG升高的胰腺癌病例中，癌细胞中仅CEA呈阳性，表明癌细胞产生CEA，而铁蛋白和BMG不产生。POA和CEA联合检测可提高胰腺癌诊断的敏感性。结论：POA可能是一种有用的肿瘤标志物，为胰腺癌的临床诊断提供有价值的信息。
Pancreatic oncofetal antigen (POA) is considered to be an oncofetal antigen for human pancreas, and its measurement seems to be useful in the diagnosis of pancreatic cancer. In this study, POA, CEA, ferritin, BMG (beta 2 microglobulin) and AFP either in sera in pancreatic juice were measured in patients with pancreatic cancer, chronic pancreatitis and other various diseases, and their diagnostic value was comparatively evaluated. POA showed the highest sensitivity for pancreatic cancer compared with CEA or others. POA and CEA in pancreatic juice showed higher sensitivity and specificity than those in serum, probably reflecting the earlier malignant status. Localization of POA was immunohistochemically observed in tissues of pancreatic cancer and fetal pancreas. In some cases of pancreatic cancer with elevated serum CEA, ferritin and BMG, only CEA was positive in cancer cells, indicating that CEA is produced from cancer cells while ferritin and BMG are not produced from them. The combined assay of POA and CEA improved sensitivity for the diagnosis of pancreatic cancer. It is concluded that POA could be a useful tumor marker providing valuable information in the clinical diagnostic system of pancreatic cancer.