The functional effects of nutrients on enterocyte proliferation and intestinal ion transport in early infancy
The functional effects of nutrients on enterocyte proliferation and intestinal ion transport in early infancy
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DOI：
10.1016/j.earlhumdev.2010.01.008
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发表时间：
2010-07-01
影响因子：
2.5
通讯作者：
Guarino, A.
中科院分区：
文献类型：
--
作者：
Buccigrossi, V.;Giannattasio, A.;Guarino, A.
营养在婴儿早期肠道发育的调节中起着关键作用，营养素能够调节几种肠道功能，包括营养吸收、离子转运、细胞生长和分化、运动和免疫调节。这种调节部分是通过单一营养素和肠上皮细胞之间的直接相互作用来实现的。两个功能-离子运输和细胞生长-是密切相关的，似乎是由营养调节。这得到了单一营养素（例如锌）刺激离子吸收并促进肠上皮细胞生长的发现的支持。有趣的是，细胞内信号的影响是相似的，并涉及丝裂原活化蛋白激酶。其他营养素也调节肠上皮细胞的功能，有证据表明，它们的作用可能取决于它们的作用侧（顶侧或底侧）和浓度。营养素和肠上皮细胞之间的相互作用的知识可以被利用，以获得临床效果，使用营养作为长期治疗肠道和非肠道疾病。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Nutrition has a key role in the modulation of the developing intestine in early infancy, and nutrients are able to modulate several intestinal functions including nutrient absorption, ion transport, cell growth and differentiation, motility and immunomodulation. Such modulation is exerted in part through a direct interaction between a single nutrient and the enterocyte. Two functions - ion transport and cell growth - are closely connected and appear to be modulated by nutrients. This is supported by the finding that a single nutrient (e.g. zinc) stimulates ion absorption and also promotes enterocyte growth. Interestingly, intracellular signalling for either effect is similar and involves mitogen-activated protein kinase. Other nutrients also modulate enterocyte function and there is evidence that their effect may depend on their side of action (apical or basolateral) and concentration. Knowledge of the interaction between nutrients and enterocytes may be exploited to obtain clinical effects using nutrition as a long-term treatment for intestinal and non-intestinal conditions. (C) 2010 Elsevier Ireland Ltd. All rights reserved.