Organic syntheses with isotopes. Part 1
Organic syntheses with isotopes. Part 1
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用同位素进行有机合成。
DOI：
10.1021/ed036p205.1
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发表时间：
1959
影响因子：
3
通讯作者：
C. J. Collins
中科院分区：
文献类型：
--
作者：
C. J. Collins
In the prelace to “Part I; Compounds of Isotopic Carbon” the authors state “there seems to be a real need for a book whichcomprehensively collects and describes the scattered information pertain-ing to isotopic synthesis.” The reviewer feels that the authors have fulfilled this need magnificently. The book is much more, however, than a compilationof synthetic procedures, since important in-formation is often given in the notes at the end of each topic pertaining to deg-radative procedures for, and mechanistic implications of, the work cited. Follow-ing an excellent Introduction (Chapter 1) in which are discussed thearrangement of the book, nomenclature of labeled com-pounds, properties and procurement of isotopes, specialized techniques, the iso-tope effect, radiation decomposition of labeled materials and health hazards, Chapters 2 through 14 cover: Acids, Acid Derivatives, Amines, Carbonic Acid Derivatives, Carbonyl Compounds, Ethers, Heterocyclic Compounds, Hydro-carbons, Hydroxy Compounds, Onium Compounds, Sugars and Sugar Derivatives, Steriods, and Vitamins. The Table of Contents is so subdivided that it can be used ordinarily to find a given synthesis without recourse to an index. The re-viewer was impressed with the compre-hensiveness of the book, which includes references not only to the open literature, but also to the many AtomicEnergy Com-mission reports of Argonne, Brookhaven, and Oak Ridge National Laboratories, the University of California Radiation Labora-tory, the Los Alamos Scientific Labora-tories, and others. Further, where several syntheses for one compound exist the au-thors have made an attempt to evaluate the most feasible method. The reviewer agrees with the authors that:“This book should not be confined in its use to the pre-parationof labeled compounds alone, but it should be of considerablegeneral interest to the organic chemist, because the procedures were usually chosen for or devel-oped to give high yields.” Any book has drawbacks and despite the fine arrangement of the Table of Con-tents, the absence of an index to Part I is particularly irksome, Since Part II, which will contain the index to both vol-umes, treats the isotopes of the halogens, hydrogen, nitrogen, oxygen, phosphorous, and sulfur, it is conceivable that some chemists will wish to own Part I and not Part II, and thus will be forced to use the book without an index. Further, although Murray and Williams appear to have developed a nomenclature for com-pounds ofisotopiccarbon which can be appliedto most of the presently known carbon-labeled compounds, such names as “benzophenone-(1, 1'),(1, 2'),(1, 3'),(1, 4'),(2, 2'),(2, 30,(2, 40,(3, 30,(3, 40,(4, 40-C142i/o"(p. 676) for ring-labeled benzophenone seem to be too cumbersome for general acceptance. Also there are cases of poor printing in the book (a formula on page 144, for example). The foregoing minorcriticisms, however, are trivial when compared with the many excellent quali-ties of the book, which appearsto have a minimum of errors and inconsistencies. In summary, Murray and Williams, who have contributed so heavily from their own laboratory to the fieldofisotopic synthe-ses, have now compiled and written an outstanding book which, in the reviewer’s opinion, will serve as a fine reference for those interested in tracer chemistry, and should be owned by any chemist working with isotopic carbon.
