Serologic evidence of widespread everglades virus activity in dogs, Florida.
Serologic evidence of widespread everglades virus activity in dogs, Florida.
复制标题
DOI：
10.3201/eid1212.060446
复制
发表时间：
2006-12
影响因子：
11.8
通讯作者：
Weaver SC
中科院分区：
文献类型：
--
作者：
Coffey LL;Crawford C;Dee J;Miller R;Freier J;Weaver SC
大沼泽地病毒（EVEV）是委内瑞拉马脑炎复合体中的一种甲病毒，在佛罗里达的啮齿动物和病媒蚊子中传播，偶尔感染人类。它引起发热性疾病，有时伴有神经系统表现。尽管先前的调查显示人类的血清阳性率较高，但EVEV感染可能诊断不足，因为该疾病的严重程度不足以保证临床就诊或未分化的表现使诊断复杂化。记录在案的EVEV活动，最近在1993年，仅限于南佛罗里达。使用狗作为哨兵，进行血清调查，以评估是否EVEV最近在佛罗里达和EVEV的空间分布是否平行的蚊子载体，库蚊cedecei。4%的狗血清含有中和EVEV抗体，许多血清阳性动物生活在比记录的EVEV活动和主要载体更北的地方。这些结果表明，EVEV在佛罗里达广泛传播，可能是人类疾病的一个重要的，未被认识的原因。
Everglades virus (EVEV), an alphavirus in the Venezuelan equine encephalitis complex, circulates among rodents and vector mosquitoes in Florida and occasionally infects humans. It causes febrile disease, sometimes accompanied by neurologic manifestations. Although previous surveys showed high seroprevalence in humans, EVEV infections may be underdiagnosed because the disease is not severe enough to warrant a clinic visit or the undifferentiated presentations complicate diagnosis. Documented EVEV activity, as recent as 1993, was limited to south Florida. Using dogs as sentinels, a serosurvey was conducted to evaluate whether EVEV circulated recently in Florida and whether EVEV's spatial distribution parallels that of the mosquito vector, Culex cedecei. Four percent of dog sera contained neutralizing EVEV antibodies, and many seropositive animals lived farther north than both recorded EVEV activity and the principal vector. These results indicate that EVEV is widespread in Florida and may be an important, unrecognized cause of human illness.