Antioxidant constituents in the dayflower (Commelina communis L.) and their α-glucosidase-inhibitory activity
Antioxidant constituents in the dayflower (Commelina communis L.) and their α-glucosidase-inhibitory activity
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DOI：
10.1007/s11418-008-0244-1
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发表时间：
2008-07-01
影响因子：
3.3
通讯作者：
Baba, Kimiye
中科院分区：
文献类型：
--
作者：
Shibano, Makio;Kakutani, Koji;Baba, Kimiye
鸭跖草（Commelina communis L.）含有1-脱氧野尻霉素（DNJ）和（2 R，3R，4 R，5 R）2，5-双（羟甲基）-3，4-二羟基吡咯烷（DMDP），有效的α-葡萄糖苷酶抑制剂。这种草药的提取物和粉末是预防2型糖尿病的重要食品原料。从紫茎泽兰地上部分中鉴定出11个黄酮苷类化合物，分别为异槲皮苷、异鼠李素-3-O-芸香糖苷、异鼠李素-3-O-β-D-葡萄糖苷、葡萄糖醇甙、大黄酚-7-O-β-D-葡萄糖苷、Orientin、牡荆素、异Orientin、异牡荆素、swertisin和flavocomelin。communis。他们的抗氧化活性进行了测定，采用1，1-二苯基-2-苦肼自由基和超氧自由基清除试验在体外试验。结果表明，甘草中主要的抗氧化成分为甘草醇苷（glucoluteolin）、Orientin、isoorientin和isoquercitrin，而isoquercitrin、isorhamnetine-3-O-rutinoside、vitexin和swertisin对大鼠肠道α-葡萄糖苷酶活性有抑制作用。
The dayflower, Commelina communis L., contains 1-deoxynojirimycin (DNJ) and (2R,3R,4R,5R)2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine (DMDP), potent alpha-glucosidase inhibitors. The extracts and powder of this herb are important food materials for prophylaxis against type 2 diabetes. Eleven flavonoid glycosides as antioxidants, isoquercitrin, isorhamnetin-3-O-rutinoside, isorhamnetin-3-O-beta-D-glucoside, glucoluteolin, chrysoriol-7-O-beta-D-glucoside, orientin, vitexin, isoorientin, isovitexin, swertisin, and flavocommelin, were identified from the aerial parts of C. communis. Their antioxidant activities were measured using in vitro assays employing the 1,1-diphenyl-2-picrylhydrazyl radical- and superoxide radical-scavenging assays. The results showed that glucoluteolin, orientin, isoorientin, and isoquercitrin are the predominant antioxidants in this herb. Moreover, isoquercitrin, isorhamnetine-3-O-rutinoside, vitexin, and swertisin inhibited the activity of alpha-glucosidase from rat intestine.