Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study
Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study
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DOI：
10.1016/j.soard.2020.01.014
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发表时间：
2020-04-01
影响因子：
3.1
通讯作者：
Pepino, Marta Yanina
中科院分区：
文献类型：
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作者：
Acevedo, Maria Belen;Teran-Garcia, Margarita;Pepino, Marta Yanina
背景资料：Roux-en-Y胃旁路术（RYGB）和袖状胃切除术（SG）是全球最常见的减肥手术，增加了酒精使用障碍的风险。这可能部分是由于手术相关的酒精药代动力学变化。另一个危险因素，在这一人群中未被探索，是对酒精镇静作用的主观反应降低。目的：评估酒精敏感性问卷（ASQ），一个简单的自我报告措施，是否可以精确定位肥胖人群中酒精敏感性降低。设置：密苏里州和伊利诺斯州的大学医学中心。设置：密苏里州和伊利诺斯州的大学医学中心。方法：在过去5年内接受过RYGB（n = 16）、SG（n = 28）或腹腔镜可调节胃束带手术（n = 11）的女性完成了术前和术后时间范围的ASQ，其中45人参加了术后口服酒精激发试验。在饮酒前和饮酒后3.5小时测量血液酒精浓度（BAC）和主观刺激和镇静。与腹腔镜可调节胃束带手术相比，RYGB和SG术后的BAC峰值更快、更高（P <0.001），与腹腔镜可调节胃束带手术相比，RYGB/SG术后ASQ评分较术前降低更多（-2.3 +/- .3对比-1.2 +/- .2; P < .05）。然而，尽管在BAC观察到的巨大变化时，摄入酒精后RYGB/SG手术，这导致在峰值BAC约50%以上的法律的驾驶限制，三分之一的这些妇女感到几乎没有酒精相关的sedative effects.Conclusions：虽然RYGB/SG显着增加了所有参与者对酒精的敏感性，有意义的个体间差异仍然存在。ASQ可能有助于识别手术后患酒精使用障碍风险增加的患者。(C)2020年美国肥胖外科学会。爱思唯尔公司出版All rights reserved.
Background: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the most common bariatric surgeries performed worldwide, increase the risk to develop an alcohol use disorder. This might be due, in part, to surgery-related changes in alcohol pharmacokinetics. Another risk factor, unexplored within this population, is having a reduced subjective response to alcohol's sedative effects.Objectives: To assess whether the alcohol sensitivity questionnaire (ASQ), a simple self-report measure, could pinpoint reduced alcohol sensitivity in the bariatric population.Setting: University medical centers in Missouri and Illinois.Setting: University medical centers in Missouri and Illinois.Methods: Women who had RYGB (n = 16), SG (n = 28), or laparoscopic adjustable gastric banding surgery (n = 11) within the last 5 years completed the ASQ for both pre- and postsurgical timeframes, and 45 of them participated in oral alcohol challenge testing postsurgery. Blood alcohol concentration (BAC) and subjective stimulation and sedation were measured before and for 3.5 hours after drinking.Results: In line with faster and higher peak BACs after RYGB and SG than laparoscopic adjustable gastric banding surgery (P < .001), postsurgery ASQ scores were more reduced from presurgery scores after RYGB/SG than after laparoscopic adjustable gastric banding surgery (-2.3 +/- .3 versus -1.2 +/- .2; P < .05). However, despite the dramatic changes in BAC observed when ingesting alcohol after RYGB/SG surgeries, which resulted in peak BAC that were approximately 50% above the legal driving limit, a third of these women felt almost no alcohol-related sedative effects.Conclusions: Although RYGB/SG dramatically increased sensitivity to alcohol in all participants, meaningful interindividual differences remained. The ASQ might help identify patients at increased risk to develop an alcohol use disorder after surgery. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.