Antifungal Nafuredin and Epithiodiketopiperazine Derivatives From the Mangrove-Derived FungusTrichoderma harzianumD13
Antifungal Nafuredin and Epithiodiketopiperazine Derivatives From the Mangrove-Derived FungusTrichoderma harzianumD13
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来自红树林源真菌哈茨木霉 D13 的抗真菌萘呋定和环硫二酮哌嗪衍生物
DOI：
10.3389/fmicb.2020.01495
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发表时间：
2020-06-26
影响因子：
5.2
通讯作者：
Zhang, Cheng-Sheng
中科院分区：
文献类型：
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作者：
Zhao, Dong-Lin;Zhang, Xi-Fen;Zhang, Cheng-Sheng
从红树林真菌Trichoderma harzipendidD 13中分离得到一个新的聚酮衍生物nafuredin C（1）、一个新的杂环二肽类化合物aciddermamide G（3）以及四个已知的生物遗传学相关化合物nafuredin A（2）、aciddermamide A（4）、aspergillazin A（5）和penisocoumarin H（6）。通过光谱分析和含时密度泛函理论-电子圆二色性（ECD）计算确定了它们的结构，包括它们的绝对构型。Trichodermamide G是一种新型的epithiodiketopiperazine衍生物，具有前所未有的含硫桥的环状体系，nafuredin C是第三种nafuredin衍生物。新化合物萘呋啶C对稻瘟病菌具有明显的抑菌活性，其最小抑菌浓度（MIC）为8.63 μ M，与阳性对照多菌灵（MIC = 3.27 μ M）在同一数量级。
A new polyketide derivative, nafuredin C (1), a novel heterocyclic dipeptide, trichodermamide G (3), together with four known biogenetically related compounds nafuredin A (2), trichodermamide A (4), aspergillazin A (5), and peniisocoumarin H (6), were isolated from the mangrove-derived fungusTrichoderma harzianumD13. Their structures, including their absolute configurations, were determined by spectroscopic analysis and time-dependent density functional theory-electronic circular dichroism (ECD) calculations. Trichodermamide G was found to be a novel epithiodiketopiperazine derivative with an unprecedented cyclic system containing a sulfur bridge, and nafuredin C represented the third nafuredin derivative of these homologous compounds. The new compound nafuredin C exhibited obvious antifungal activity againstMagnaporthe oryzaewith a minimum inhibitory concentration (MIC) of 8.63 mu M, which is on the same order of magnitude as the positive control carbendazim (MIC = 3.27 mu M).