Origin and Function of Structural Diversity in the Plant Specialized Metabolome.
Origin and Function of Structural Diversity in the Plant Specialized Metabolome.
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DOI：
10.3390/plants10112393
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发表时间：
2021-11-06
期刊：
影响因子：
--
通讯作者：
Dauwe R
中科院分区：
文献类型：
--
作者：
Desmet S;Morreel K;Dauwe R
植物专化代谢组由多种结构和功能不同的代谢物组成，不同物种的代谢物是不同的。特化代谢产物在响应环境变化、非生物或生物胁迫以及植物生长发育中发挥作用。在其基础上，专门化代谢由四条主要途径组成，每条途径都从几个不同的初级代谢前体开始，并导致不同的基本碳骨架核心结构：多酮和脂肪酸衍生物、萜类、生物碱和酚类。然而，专门化代谢中的结构多样性随着随后的每一次修饰而呈指数级扩大。我们在这里回顾了结构多样性的主要来源，并质疑是否可以将特定的角色归因于每个不同的结构。我们重点讨论了不同的核心结构和修饰对类黄酮抗氧化活性的影响，以及氧化偶联反应产生的多样性。我们认为，许多氧化偶联产物，由最初的自由基清除触发，可能在Se中没有功能，但可能被酶促循环为有效的抗氧化剂。我们进一步讨论了多种修饰(糖基化、酰化、戊烯基化)所产生的广泛的结构变化，高分子量共轭化合物和聚酯的形成，以及特殊代谢的可塑性。我们提请注意，为了研究植物专门化代谢物的功能，有必要使用非靶向的方法来鉴定复杂的、多重修饰的和共轭的化合物。
The plant specialized metabolome consists of a multitude of structurally and functionally diverse metabolites, variable from species to species. The specialized metabolites play roles in the response to environmental changes and abiotic or biotic stresses, as well as in plant growth and development. At its basis, the specialized metabolism is built of four major pathways, each starting from a few distinct primary metabolism precursors, and leading to distinct basic carbon skeleton core structures: polyketides and fatty acid derivatives, terpenoids, alkaloids, and phenolics. Structural diversity in specialized metabolism, however, expands exponentially with each subsequent modification. We review here the major sources of structural variety and question if a specific role can be attributed to each distinct structure. We focus on the influences that various core structures and modifications have on flavonoid antioxidant activity and on the diversity generated by oxidative coupling reactions. We suggest that many oxidative coupling products, triggered by initial radical scavenging, may not have a function in se, but could potentially be enzymatically recycled to effective antioxidants. We further discuss the wide structural variety created by multiple decorations (glycosylations, acylations, prenylations), the formation of high-molecular weight conjugates and polyesters, and the plasticity of the specialized metabolism. We draw attention to the need for untargeted methods to identify the complex, multiply decorated and conjugated compounds, in order to study the functioning of the plant specialized metabolome.
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影响因子：
3.8
作者：
Carneiro, FJC;Boralle, N;Lopes, LMX
通讯作者：
Lopes, LMX
影响因子：
3.8
作者：
Baumert, A;Milkowski, C;Strack, D
通讯作者：
Strack, D
影响因子：
7.4
作者：
Berenbaum, May R.;Zangerl, Arthur R.
通讯作者：
Zangerl, Arthur R.
DOI：
10.3390/molecules21111422
发表时间：
2016-10-27
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Arroyo-Currás N;Rosas-García VM;Videa M
通讯作者：
Videa M
影响因子：
2.9
作者：
Bar-Even, Arren;Noor, Elad;Milo, Ron
通讯作者：
Milo, Ron