Epidemiology of hepatocellular carcinoma
Epidemiology of hepatocellular carcinoma
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DOI：
10.1016/s0300-483x(02)00251-2
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发表时间：
2002-12-27
期刊：
影响因子：
4.5
通讯作者：
Kew, MC
中科院分区：
文献类型：
--
作者：
Kew, MC
肝细胞癌在世界上许多人口最多的国家发病率高，病程多为暴发性，对保守治疗反应差，有症状时切除率低，切除和肝移植后复发率高，预后差，现已被认为是主要的恶性肿瘤之一。肝细胞癌是最常见的肝脏原发恶性肿瘤。相对于其他肿瘤，它的总发病率排名第五(男性排名第五，女性排名第八)，年死亡率排名第四。据估计，每年新诊断的肝细胞癌病例有372000例，占所有人类新发癌症的4.6%(男性6.3%，女性2.7%)。肿瘤的年死亡率实际上与其年发病率相同。发病率最高的地区是东亚和东南亚、一些西太平洋岛屿和撒哈拉以南非洲地区。在东欧和南欧、加勒比海地区、中美洲和西亚发现了中间发病率。肝细胞癌在其余国家并不常见。男性比女性更容易受到影响。发病率一般随着年龄的增长而增加，尽管在非洲黑人和华裔人口中有一定的向年轻化分布的转变。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Because of its high incidence in many of the most populous countries in the world, its often fulminant course, poor response to conservative treatment, low resectabilty rate when symptomatic, high recurrence rate after resection and liver transplantation, and grave prognosis, hepatocellular carcinoma is now regarded as one of the major malignant diseases. Hepatocellular carcinoma is the most common primary malignant turnour of the liver. Relative to other tumours, it ranks fifth in overall frequency (fifth in men and eighth in women) and fourth in annual mortality rate. An estimated 372 000 new cases of hepatocellular carcinoma are diagnosed each year, constituting 4.6% of all new human cancers (6.3% in men; 2.7% in women). The annual mortality rate from the tumour is virtually the same as its annual incidence. The highest incidences occur in eastern and southeastern Asia, some of the Western Pacific islands, and sub-Saharan Africa. Intermediate incidences are found in eastern and southern Europe, the Caribbean, Central America, and Western Asia. Hepatocellular carcinoma is uncommon in the remaining countries. Men are affected more often than are women. The incidence generally increases with increasing age, although there is a definite shift towards a younger age distribution in black African and ethnic Chinese populations. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.