Framework for a protein ontology.
Framework for a protein ontology.
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DOI：
10.1186/1471-2105-8-s9-s1
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发表时间：
2007-11-27
影响因子：
3
通讯作者：
Wu CH
中科院分区：
文献类型：
--
作者：
Natale DA;Arighi CN;Barker WC;Blake J;Chang TC;Hu Z;Liu H;Smith B;Wu CH
生物医学本体作为基因组和蛋白质组学研究的关键工具，其中需要整合不同的资源中的复杂数据。但是，人类的疾病是Snomed CT或ICD10已经设计了蛋白质本体（PRO）来促进蛋白质注释并指导新实验。 ）变异，替代剪接，蛋白水解裂解和其他翻译后修饰）。在这里，我们描述了PRO的初始发展，使用与转化生长因子-Beta和骨形态发生蛋白信号通路有关的人和小鼠蛋白。
Biomedical ontologies are emerging as critical tools in genomic and proteomic research, where complex data in disparate resources need to be integrated. A number of ontologies describe properties that can be attributed to proteins. For example, protein functions are described by the Gene Ontology (GO) and human diseases by SNOMED CT or ICD10. There is, however, a gap in the current set of ontologies – one that describes the protein entities themselves and their relationships. We have designed the PRotein Ontology (PRO) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modifications). PRO will allow the specification of relationships between PRO, GO and other ontologies in the OBO Foundry. Here we describe the initial development of PRO, illustrated using human and mouse proteins involved in the transforming growth factor-beta and bone morphogenetic protein signaling pathways.