Effect of naloxone on posttraumatic ischemia in experimental spinal contusion.
Effect of naloxone on posttraumatic ischemia in experimental spinal contusion.
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DOI：
10.3171/jns.1981.55.2.0209
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发表时间：
1981-08
影响因子：
4.1
通讯作者：
Wise Young;Eugene S. Flamm;H. Demopoulos;J. Tomasula;V. Decrescito
中科院分区：
文献类型：
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作者：
Wise Young;Eugene S. Flamm;H. Demopoulos;J. Tomasula;V. Decrescito
在遭受 400 gm-cm 胸脊髓挫伤的猫中研究了纳洛酮对血流和体感诱发电位的影响。受伤后 45 至 60 分钟，8 只猫接受 10 mg/kg 纳洛酮治疗，11 只猫接受 10 ml 盐水代替纳洛酮，6 只猫既没有受伤也没有接受治疗。氢气清除率用于测量挫伤部位侧白柱的血流量。静脉注射纳洛酮可显着提高侧柱白质的血流速度。受伤后 2 小时，接受盐水治疗的猫的平均血流量下降至受伤前流量的 50%（p 大于 0.01），而接受纳洛酮治疗的猫的平均血流量增加 6%（p 大于 0.50），未受伤的猫增加 12%（p 大于 0.50）。受伤后第 3 小时，流量分别比受伤前下降 47%（p 小于 0.01）和 6%（p 大于 0.50），并增加 15%（p 大于 0.50）。接受纳洛酮治疗的猫在受伤 24 小时后感觉功能和体感诱发电位显着保留。 24 小时后，所有接受纳洛酮治疗的猫均恢复了反应，而接受盐水治疗的猫中只有 11% 恢复了反应。该事件组合偶然发生的概率为 0.0030。作者得出结论，纳洛酮可能有助于治疗脊髓损伤。其作用机制尚不清楚。
The effect of naloxone on blood flow and somatosensory evoked potentials was studied in cats subjected to 400 gm-cm contusion injuries of the thoracic spinal cord. Eight cats were treated with 10 mg/kg naloxone 45 to 60 minutes after injury, 11 cats were given 10 ml of saline instead of naloxone, and six cats were neither injured nor treated. Hydrogen clearance was used to measure blood flow in the lateral white columns at the contusion site. Naloxone, given intravenously, significantly inproved the blood flow rates in the lateral column white matter. At 2 hours after injury, the mean blood flow in the saline-treated cats fell to 50% (p greater than 0.01) of preinjury flow rates, whereas it increased 6% (p greater than 0.50) in naloxone-treated cats, and 12% (p greater than 0.50) in uninjured cats. At the 3rd hour after injury, the respective flows fell 47% (p less than 0.01), and 6% (p greater than 0.50), and increased 15% (p greater than 0.50) of the preinjury flow rates. The naloxone-treated cats had striking preservation of sensory function and somatosensory evoked potentials at 24 hours after injury. At 24 hours, responses had returned in all the naloxone-treated cats and in only 11% of the saline-treated cats. The probability of this combination of events occurring by chance is 0.0030. The authors conclude that naloxone may be useful for the treatment of spinal cord injury. The mechanism of the effect is unknown.