Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
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DOI：
10.1016/s0378-5173(02)00080-7
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发表时间：
2002-05-15
影响因子：
5.8
通讯作者：
Saettone, MF
中科院分区：
文献类型：
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作者：
Cavalli, R;Gasco, MR;Saettone, MF
本研究的目的是评估固体脂质纳米粒子（SLN）作为局部眼部递送妥布霉素（JOB）的载体。 SLN 处于胶体尺寸范围内（平均直径低于 100 nm；多分散指数低于 0.2），并含有 2.5% TOB 与十六烷基磷酸酯的离子对复合物。使用不含药物的荧光 SLN (F-SLN) 测试了 SLN 在兔眼中的眼前保留：与荧光水溶液相比，它们在角膜表面和结膜囊中保留的时间更长。将含有 0.3% w/v TOB 的负载 TOB 的 SLN (TOB-SLN) 悬浮液局部给予兔子，并测定 TOB 的房水浓度长达 6 小时。与标准市售滴眼液给予等剂量的 TOB 相比，TOB-SLN 在房水中产生显着更高的 TOB 生物利用度。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Aim of this study was to evaluate solid lipid nanoparticles (SLN) as carriers for topical ocular delivery of tobramycin JOB). The SLN were in the colloidal size range (average diameter below 100 nm; polydispersity index below 0.2) and contained 2.5% TOB as ion-pair complex with hexadecyl phosphate. The preocular retention of SLN in rabbit eyes was tested using drug-free, fluorescent SLN (F-SLN): these were retained for longer times on the corneal surface and in the conjunctival sac when compared with an aqueous fluorescent solution. A suspension of TOB-loaded SLN (TOB-SLN) containing 0.3% w/v TOB was administered topically to rabbits, and the aqueous humour concentration of TOB was determined up to six hours. When compared with an equal dose of TOB administered by standard commercial eyedrops, TOB-SLN produced a significantly higher TOB bioavailability in the aqueous humour. (C) 2002 Elsevier Science B.V. All rights reserved.