Body Mass Index Is a Stronger Predictor than the Metabolic Syndrome for Future Asthma in Women The Longitudinal CARDIA Study
Body Mass Index Is a Stronger Predictor than the Metabolic Syndrome for Future Asthma in Women The Longitudinal CARDIA Study
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DOI：
10.1164/rccm.201303-0457oc
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发表时间：
2013-08-01
影响因子：
24.7
通讯作者：
Sood, Akshay
中科院分区：
文献类型：
--
作者：
Assad, Nour;Qualls, Clifford;Sood, Akshay
基本原理：据推测，代谢综合征解释了身体质量指数（BMI）和成人哮喘之间的关联。Objectives：我们的目的是纵向比较的相对强度的协会的代谢综合征和BMI与事件asthma in adults.Methods：我们包括4,619名合格的参与者在冠状动脉风险发展的年轻人（CARDIA）队列超过25年。突发性哮喘的定义是由新的自我报告的提供者哮喘诊断加上哮喘症状的存在和/或哮喘药物的使用。进行了考克斯比例风险分析。测量和主要结果：在25年的随访中，602名受试者（417名女性和185名男性）发生了哮喘。代谢综合征可预测女性而非男性的哮喘发作（未校正的风险比分别为1.50和0.98; P = 0.01和0.93）。BMI在女性中具有类似的预测关联，但在男性中则没有（未校正的风险比，每5个BMI单位分别为1.19和1.04; P < 0.001和0.60）。在调整BMI后，代谢综合征与女性哮喘发病的相关性不再具有统计学意义（P = 0.44）。相反，在调整代谢综合征后，女性中BMI与哮喘发病率的相关性仍然具有统计学意义（P = 0.01）。在逐步回归模型中，BMI是一个比代谢综合征更强的预测因子（P = 0.001）。结论：BMI是一个比代谢综合征更强的女性哮喘发病预测因子。其他不属于代谢综合征的肥胖相关因素可能在女性BMI-哮喘相关性中发挥作用。
Rationale: It is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults.Objectives: Our objective was to longitudinally compare the relative strengths of the associations of the metabolic syndrome and BMI with incident asthma in adults.Methods: We included 4,619 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort followed over 25 years. Incident asthma was defined by a new self-reported provider asthma diagnosis plus either the presence of asthma symptoms and/or use of asthma medications. Cox proportional hazard analyses were performed.Measurements and Main Results: Six hundred two subjects (417 women and 185 men) developed incident asthma over 25 years of follow-up. Metabolic syndrome predicted incident asthma among women but not men (unadjusted hazard ratios, 1.50 and 0.98; P = 0.01 and 0.93, respectively). BMI had a similar predictive association among women but not men (unadjusted hazard ratios, 1.19 and 1.04 per 5 units of BMI; P < 0.001 and 0.60, respectively). The association of metabolic syndrome with incident asthma in women was no longer statistically significant after adjustment for BMI (P = 0.44). In contrast, the association of BMI with incident asthma in women remained statistically significant after adjusting for the metabolic syndrome (P = 0.01). In a stepwise model, BMI was a stronger predictor than the metabolic syndrome (P = 0.001).Conclusions: BMI is a stronger predictor of incident asthma among women than the metabolic syndrome. Other obesity-associated factors that are not a part of the metabolic syndrome may play a role in the BMI-asthma association in women.