Preptin is a new predictor of coronary artery calcification
Preptin is a new predictor of coronary artery calcification
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Preptin 是冠状动脉钙化的新预测因子
DOI：
10.1016/j.cca.2018.06.038
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发表时间：
2018
影响因子：
5
通讯作者：
Li Tao
中科院分区：
文献类型：
--
作者：
Li Bo;Li Yuhua;Zhang Tongtong;Song Litao;Lei Chengbin;Zhao Yan;He Bing;Zhao Yunhe;Yin Bo;Jin Xiaodong;Li Tao
背景我们旨在评估 preptin 水平升高是否与冠状动脉钙化 (CAC) 相关。方法招募了 220 名疑似心血管疾病的参与者。采用320排探测器动态容积CT测量CAC，将患者分为2组：非CAC组（Agatston评分=0）和CAC组（Agatston评分>0）。结果与非CAC组相比，CAC组血清preptin水平显着升高。在逻辑回归分析中，preptin 以及年龄、性别、高血压病史和 β 受体阻滞剂使用史是 CAC 评分阳性的独立预测因子。与其他五分位数相比，preptin 最高的五分位数患者的 CAC 水平较高。二元逻辑回归分析显示，最高的 preptin 五分位患者的 CAC 水平升高的比值比比其他 4 个五分位患者高 2.9 倍。 结论 这项研究表明，血清 preptin 与冠状动脉钙化相关。
BackgroundWe aimed to assess whether an elevated preptin level is associated with coronary artery calcification (CAC).MethodsTwo hundred and twenty participants with suspected cardiovascular disease were recruited. CAC was measured using 320-row-detector dynamic volume CT, and the patients were divided into 2 groups: the non-CAC group (with an Agatston score = 0) and the CAC group (with an Agatston score > 0).ResultsThe serum preptin level was significantly elevated in the CAC group compared with the non-CAC group. In logistic regression analysis, preptin, as well as age, gender, hypertension history and history of β-blocker use, were independent predictors of a positive CAC score. The highest preptin quintile of patients had a higher CAC level compared with other quintiles. Binary logistic regression analyses showed that the highest preptin quintile had a 2.9-time increased odds ratio of an elevated CAC level than the other 4 quintile patients.ConclusionsThis study demonstrated that serum preptin was associated with coronary artery calcification.