Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex
Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex
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DOI：
10.1038/sj.npp.1300490
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发表时间：
2004-09-01
影响因子：
7.6
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Chudasama, Y;Robbins, TW
越来越多的证据表明，多巴胺能投射到前额叶皮层（PFC）调节注意力和工作记忆过程，这可能与D-1受体机制特异性多巴胺活性不足或过度有关。我们研究了双侧前额皮质内注入D-1激动剂（SKF 81297）对一项新任务的影响，该任务专门设计用于评估动物在同一测试过程中注意视觉目标（0.7或0.5秒）并在可变延迟（0.16秒）内记住目标位置的能力。低剂量SKF 81297（0.01杯）双侧前额叶输注在整个测试过程中对视觉注意和记忆没有影响。中等剂量（0.06杯）优先增加了对刺激目标的注意，但仅在0.7秒的持续时间内改善了对刺激的记忆，尽管是以延迟无关的方式。高剂量（0.3杯）的D-1激动剂也增加了注意力的准确性。然而，只有在更具注意力挑战性的条件下（0.5 s），高剂量也会对刺激目标产生基线延迟依赖性的记忆调节。具体来说，短时延迟下的良好记忆受损，而长时延迟下的不良记忆得到改善。这些数据首次证明，多巴胺D-1受体刺激足以提高注意力的准确性，也可以以延迟依赖的方式破坏和促进短期工作记忆的表现。
Converging evidence suggests that dopaminergic projections to the prefrontal cortex (PFC) modulate both attention and working memory processes that may be related to either insufficient or excessive dopamine activity specific to a D-1 receptor mechanism. We examined the effects of bilateral intraprefrontal cortical infusions of the D-1 agonist (SKF 81297) on a novel task specifically designed to assess the animals' ability to attend to a visual target (0.7 or 0.5 s) and then remember the location of that target over a variable delay ( 0 16 s) within the same test session. Bilateral prefrontal infusions of the low dose of SKF 81297 (0.01 mug) had no effect on visual attention or memory throughout the entire testing schedule. The medium ( 0.06 mug) dose preferentially increased attention to the stimulus target but only improved memory for that stimulus at a duration of 0.7 s, although in a delay-independent manner. The high dose (0.3 mug) of the D-1 agonist also increased attentional accuracy. However, it was only under the more attention challenging condition ( 0.5 s) that this high dose also produced a baseline delay-dependent modulation of memory for the stimulus target. Specifically, good memory at the short delay was impaired and poor memory at the long delay was improved. These data provide the first demonstration that dopamine D-1 receptor stimulation sufficient to improve attentional accuracy, can also disrupt, and facilitate short-term working memory performance in a delay-dependent manner.