Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation
Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation
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DOI：
10.1038/sj.jp.7211447
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发表时间：
2006-03-01
影响因子：
2.9
通讯作者：
Georgieff, M. K.
中科院分区：
文献类型：
--
作者：
Davis, E. P.;Townsend, E. L.;Georgieff, M. K.
目的：为了研究产前β-内酰胺酶（AB）暴露对产后应激调节的影响，研究设计：14名出生于妊娠28 - 30周的AB暴露婴儿在产后第1周和妊娠34周在新生儿重症监护室接受评估。9名出生于孕34周未接受AB治疗的婴儿作为孕后年龄对照组进行评价。唾液皮质醇，心率，和行为进行了测量，在基线和在响应一个heelstick blood draw.Results：重复测量方差分析显示，这两组显示的心率和行为困扰的压力源的增加。皮质醇的反应，但是，在AB治疗的婴儿在这两个assessment.Conclusion：AB治疗的后果下丘脑垂体-肾上腺（HPA）轴的调节，持续至少4至6周出生后，表明长期影响的研究是必要的。
Objective: To examine the consequences of antenatal betamethasone ( AB) exposure on postnatal stress regulation.Study design: Fourteen AB exposed infants born at 28 - 30 weeks' gestation were assessed in the NICU during postnatal week 1 and at 34 weeks postconception. Nine infants born at 34 weeks gestation without AB treatment were evaluated as a postconceptional age comparison group. Salivary cortisol, heart rate, and behavior were measured at baseline and in response to a heelstick blood draw.Results: Repeated measures ANOVAs revealed that both groups displayed an increase in heart rate and behavioral distress in response to the stressor. The cortisol response, however, was blunted in AB-treated infants at both assessments.Conclusion: AB treatment has consequences for hypothalamic pituitary - adrenal (HPA) axis regulation that persist for at least four to six weeks after birth, indicating that studies of long-term effects are warranted.