In situ electrochemical distance tunneling spectroscopy of ds-DNA molecules.
In situ electrochemical distance tunneling spectroscopy of ds-DNA molecules.
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DOI：
10.1021/la053224
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发表时间：
2006-03
期刊：
影响因子：
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通讯作者：
E. Wierzbiński;Justin Arndt;William J. Hammond;K. Słowiński
中科院分区：
文献类型：
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作者：
E. Wierzbiński;Justin Arndt;William J. Hammond;K. Słowiński
The electrical conductance of ds-DNA duplexes containing 8-14 base pairs modified at both ends with a -(CH(2))(6)-SH linker was measured in a buffered aqueous solution using electrochemically controlled distance tunneling spectroscopy. The tunneling experiment with self-complementary 5'-(GC)(n)()-3'-(CH(2))(6)-SH (n = 4-7) duplexes attached covalently to a gold STM tip and a Au(111) electrode shows a wide distribution of currents independent of the ds-DNA length. The voltage-induced horizontal orientation of ds-DNA within the junction results in decreased electrical conductance. The lower currents are also observed for ds-DNA molecules containing a single CA base mismatch.
