Endocytosis of tight junction proteins and the regulation of degradation and recycling.
Endocytosis of tight junction proteins and the regulation of degradation and recycling.
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DOI：
10.1111/nyas.13346
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发表时间：
2017-06
影响因子：
5.2
通讯作者：
Andjelkovic AV
中科院分区：
文献类型：
--
作者：
Stamatovic SM;Johnson AM;Sladojevic N;Keep RF;Andjelkovic AV
紧密连接（TJ）蛋白质从质膜的内化是调节TJ可塑性和功能在上皮和内皮屏障组织的关键机制。一旦内化，TJ蛋白进入复杂的囊泡机制，其中进一步的运输直接依赖于调节TJ蛋白的分选和命运的起始刺激和下游信号传导途径，以及细胞和屏障反应。内化的TJ蛋白的命运是再循环到质膜或分选到晚期内体和降解。这篇综述强调了最近的进展，我们的知识内吞和囊泡运输的TJ蛋白在上皮细胞和内皮细胞。对这些过程的更深入理解可以允许开发调节药物递送的屏障渗透性或预防疾病状态下的屏障功能障碍的方法。
Internalization of tight junction (TJ) proteins from the plasma membrane is a pivotal mechanism regulating TJ plasticity and function in both epithelial and endothelial barrier tissues. Once internalized, the TJ proteins enter complex vesicular machinery, where further trafficking is directly dependent on the initiating stimulus and downstream signaling pathways that regulate the sorting and destiny of TJ proteins, as well as on cell and barrier responses. The destiny of internalized TJ proteins is recycling to the plasma membrane or sorting to late endosomes and degradation. This review highlights recent advances in our knowledge of endocytosis and vesicular trafficking of TJ proteins in both epithelial and endothelial cells. A greater understanding of these processes may allow for the development of methods to modulate barrier permeability for drug delivery or preventing barrier dysfunction in disease states.