Relationship between Current Psychological Symptoms and Future Risk of Asthma Outcomes: A 12-Month Prospective Cohort Study
Relationship between Current Psychological Symptoms and Future Risk of Asthma Outcomes: A 12-Month Prospective Cohort Study
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当前心理症状与未来哮喘结果风险之间的关系：一项为期 12 个月的前瞻性队列研究
DOI：
10.3109/02770903.2011.631238
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发表时间：
2011-12-01
影响因子：
1.9
通讯作者：
Ji, Yu-Lin
中科院分区：
文献类型：
--
作者：
Wang, Gang;Zhou, Ting;Ji, Yu-Lin
背景哮喘受试者更容易受到心理症状的影响，但目前尚不确定心理症状是否与未来的哮喘风险有关。Objective.探讨当前心理症状与未来哮喘风险之间的关系。方法.我们对297例哮喘患者进行了为期12个月的前瞻性队列研究。评估基线时的心理症状、肺功能、哮喘控制测试和哮喘生活质量问卷。每月监测哮喘结局，包括急性发作、计划外访视、急诊访视、入院、重症监护室入院和住院时间。分析至首次哮喘结局的时间。此外，使用逻辑回归模型计算心理症状与哮喘结局未来风险之间的关联，作为校正的相对风险（RR）。结果将哮喘患者分为无焦虑抑郁症状组（NAD组，n = 102）、有焦虑抑郁症状组（A/D组，n = 68）和有焦虑抑郁症状组（AD组，n = 120）。Logistic回归模型显示，AD组的哮喘患者（而非A/D组）的计划外访视和急诊访视的校正RR增加（RR = 2.33，95%置信区间（CI）= [1.50，3.61]; RR = 3.13，95% CI = [1.90，5.17]）。有心理症状的患者首次哮喘发作、非计划就诊和急诊就诊的时间短于无心理症状的患者（均P <0.001）。结论目前的心理症状，特别是焦虑和抑郁，独立预测未来的风险哮喘的结果。周婷和王兰对这项研究的贡献相当。
Background. Subjects with asthma are more susceptible to psychological symptoms, but it is uncertain whether psychological symptoms are linked to future risk of asthma outcomes. Objective. To investigate the relationship between current psychological symptoms and future risk of asthma outcomes. Methods. We conducted a prospective cohort study with a 12-month follow-up period of 297 patients with asthma. Psychological symptoms, lung function, asthma control test, and Asthma Quality of Life Questionnaire at baseline were assessed. Asthma outcomes including exacerbations, unplanned visits, emergency visits, hospital admissions, intensive care unit admissions, and length of hospital stays were monitored monthly. The time to the first asthma outcomes was analyzed. Furthermore, the association between psychological symptoms and future risk of asthma outcomes was calculated as adjusted relative risk (RR) using logistic regression models. Results. The asthma patients were assigned to one of three groups: neither anxiety nor depression symptoms (NAD, n = 102), either anxiety or depression symptoms (A/D, n = 68), or anxiety and depression symptoms (AD, n = 120). Logistic regression models indicated that asthma patients in the AD group, but not the A/D group, had an increased adjusted RR for unplanned visits and emergency visits (RR = 2.33, 95% confidence interval (CI) = [1.50, 3.61]; and RR = 3.13, 95% CI = [1.90, 5.17], respectively). The time to the first asthma outcomes including exacerbations, unplanned visits, and emergency visits was shorter in patients with psychological symptoms than those without (all p < .001). Conclusion. Current psychological symptoms, especially anxiety combined with depression, independently predict the future risk of asthma outcomes. Ting Zhou and Lan Wang contributed equally to this study.