Healthy Eating Index and C-reactive protein concentration: findings from the National Health and Nutrition Examination Survey III, 1988-1994
Healthy Eating Index and C-reactive protein concentration: findings from the National Health and Nutrition Examination Survey III, 1988-1994
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DOI：
10.1038/sj.ejcn.1602070
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发表时间：
2005-02-01
影响因子：
4.7
通讯作者：
Liu, S
中科院分区：
文献类型：
--
作者：
Ford, ES;Mokdad, AH;Liu, S
目的：研究膳食质量是否与C反应蛋白浓度相关。设计：采用第三次全国健康与营养检查调查数据的横断面研究（1988-1994）。设置：美国人口的代表性样本。受试者：总共13811名年龄大于或等于20岁的男性和女性。干预措施：我们研究了健康饮食指数（HEI）和血清C反应蛋白浓度之间的横截面关系，HEI是根据美国人饮食指南衡量饮食质量的一种方法。结果：在调整年龄、性别、种族、教育程度、吸烟状况、可替宁浓度、体重指数、腰臀比、阿司匹林使用、饮酒、体力活动水平和能量摄入后，在logistic回归分析中，HEI评分与C反应蛋白浓度升高呈负相关（每10个单位变化的比值比：0.92;第95个置信区间（CI）：0.86-0.99）。在这些成分中，只有谷物消费得分与C反应蛋白浓度升高呈负相关。与谷物摄入量最低的五分位数的参与者相比，第二，第三，第四和第五分位数的参与者C反应蛋白浓度升高的调整优势比为0.87（95th CI：0.67，1.12）、0.85（95th CI：0.69，1.06）、0.79（95th CI：0.65，0.96）、0.68（95th CI：0.52，0.88）。我们的调查结果需要确认。
Objective: To examine whether diet quality is associated with C-reactive protein concentration.Design: Cross-sectional study using data from the Third National Health and Nutrition Examination Survey (1988-1994).Setting: Representative sample of the US population.Subjects: A total of 13 811 men and women aged greater than or equal to20 y.Interventions: We examined the cross-sectional associations between the Healthy Eating Index (HEI), a measure of diet quality according to the Dietary Guidelines for Americans, and serum C-reactive protein concentration. Dietary information was assessed using a 24-h recall.Results: After adjustment for age, sex, race or ethnicity, education, smoking status, cotinine concentration, body mass index, waist-hip-ratio, aspirin use, alcohol use, physical activity level, and energy intake, HEI score was inversely associated with an elevated C-reactive protein concentration in logistic regression analysis (odds ratio per 10 unit change: 0.92; 95th confidence interval (CI): 0.86-0.99). Among the components, only the score for grain consumption was inversely associated with an elevated C-reactive protein concentration. Compared with participants in the lowest quintile of number of servings of grain consumption, the adjusted odds ratios of having an elevated C-reactive protein concentration for participants in the second, third, fourth, and fifth quintiles were 0.87 (95th CI: 0.67, 1.12), 0.85 (95th CI: 0.69, 1.06), 0.79 (95th CI: 0.65, 0.96), and 0.68 (95th CI: 0.52, 0.88), respectively.Conclusions: Grain consumption may reduce inflammation. Our findings require confirmation.