In situ-gelling, erodible N-isopropylacrylamide copolymers
In situ-gelling, erodible N-isopropylacrylamide copolymers
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DOI：
10.1002/mabi.200500029
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发表时间：
2005-07-14
影响因子：
4.6
通讯作者：
Vernon, B
中科院分区：
文献类型：
--
作者：
Lee, BH;Vernon, B
采用不同摩尔比的单体制备n-异丙基丙烯酰胺、2-羟乙基甲基丙烯乳酸[(HEMA)-乳酸]和丙烯酸（AAc）共聚物，制备具有一定浓度以上凝胶性能的共聚物，用于生物可降解的原位凝胶材料。共聚物在生理条件下原位形成凝胶。由于hema -乳酸的疏水性，共聚物的凝胶温度随着共聚物中hema -乳酸含量的增加而降低，由于AAc的亲水性，共聚物的凝胶温度随着AAc含量的增加而升高。凝胶在37℃时再溶解，由于hema -乳酸悬垂基团的水解，其lcst在37℃以上增加。
Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups.