AMPA receptor trafficking: a road map for synaptic plasticity.
AMPA receptor trafficking: a road map for synaptic plasticity.
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DOI：
10.1124/mi.3.7.375
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发表时间：
2003-10-01
影响因子：
--
通讯作者：
Esteban, Jose A
中科院分区：
文献类型：
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作者：
Esteban, Jose A
大脑中的大多数兴奋性传递由α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）型谷氨酸受体（AMPA受体）介导。因此，这些受体在突触上的存在必须仔细调节，以确保正确的神经元通信。有趣的是，AMPA受体并不是突触的静态成分。相反，它们会随着神经元的活动而不断地被传递到突触内外。AMPA受体的这种动态行为是在大脑发育过程中以及在经验依赖性可塑性过程中改变突触强度的重要机制。AMPA受体运输涉及蛋白质-蛋白质相互作用的复杂网络，其开始于受体的生物合成，继续其沿沿着运输，并结束于其局部插入和从突触移除。调节这些过程的分子和细胞机制，以及它们对突触可塑性的重要性，现在开始被揭开。
Most excitatory transmission in the brain is mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPA receptors). Therefore, the presence of these receptors at synapses has to be carefully regulated in order to ensure correct neuronal communication. Interestingly, AMPA receptors are not static components of synapses. On the contrary, they are continuously being delivered and removed in and out of synapses in response to neuronal activity. This dynamic behavior of AMPA receptors is an important mechanism to modify synaptic strength during brain development and also during experience-dependent plasticity. AMPA receptor trafficking involves an intricate network of protein-protein interactions that start with the biosynthesis of the receptors, continues with their transport along dendrites, and ends with their local insertion and removal from synapses. The molecular and cellular mechanisms that regulate each of these processes, and their importance for synaptic plasticity, are now starting to be unraveled.