EXPERIMENTAL INDUCTION OF BETA-AMYLOID PLAQUES AND CEREBRAL ANGIOPATHY IN PRIMATES
EXPERIMENTAL INDUCTION OF BETA-AMYLOID PLAQUES AND CEREBRAL ANGIOPATHY IN PRIMATES
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DOI：
10.1111/j.1749-6632.1993.tb23057.x
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发表时间：
1993-01-01
期刊：
影响因子：
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通讯作者：
BRUTON, CJ
中科院分区：
文献类型：
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作者：
BAKER, HF;RIDLEY, RM;BRUTON, CJ
6-7 年前，用早发性阿尔茨海默病患者的脑组织进行脑内接种，在 3 只中年普通狨猴 (Callithrix jacchus) 的大脑中发现了中等数量的淀粉样斑块，并伴有嗜银营养不良性神经突和脑淀粉样血管病 (CAA)，但没有发现神经原纤维缠结 (NFT)。斑块和血管淀粉样蛋白被β(A4)-蛋白抗体染色呈阳性。来自同一群体的 3 只年龄匹配的对照狨猴的大脑没有显示出这些神经病理学特征。在狨猴的大脑中也发现了β-淀粉样斑块和CAA（但没有海绵状脑病），该狨猴接种了患有朊病毒病并伴有β-淀粉样斑块和CAA的患者的脑组织。在两只接种了老年患者脑组织的狨猴的大脑中偶尔发现了β-淀粉样斑块。在其他 6 只比接种的狨猴年龄更大的狨猴、另外 10 只稍微年轻但几年前接种了不含 β-淀粉样蛋白的脑组织的狨猴和 10 只接受过各种神经外科手术的年轻狨猴中，没有发现 β-淀粉样蛋白斑块和 CAA。这些结果表明β-淀粉样变性是一个可传播的过程。
Moderate numbers of amyloid plaques with associated argyrophilic dystrophic neurites and cerebral amyloid angiopathy (CAA) but no neurofibrillary tangles (NFTs) were found in the brains of 3 middle-aged common marmosets (Callithrix jacchus) inoculated intracerebrally (i.c.) 6-7 years earlier with brain tissue from a patient with early onset Alzheimer's disease. The plaques and vascular amyloid stained positively with antibodies to beta(A4)-protein. The brains of 3 age-matched control marmosets from the same colony did not show these neuropathological features. beta-amyloid plaques and CAA (but no spongiform encephalopathy) were also found in the brain of a marmoset inoculated with brain tissue from a patient with prion disease with concomitant beta-amyloid plaques and CAA. An occasional beta-amyloid plaque was found in the brains of two marmosets inoculated with brain tissue from elderly patients. No beta-amyloid plaques nor CAA were found in 6 other marmosets who were older than the inoculated marmosets, 10 further marmosets who were slightly younger but who had been inoculated several years previously with brain tissue which did not contain beta-amyloid, and 10 younger marmosets who had been subjected to various neurosurgical procedures. These results suggest that beta-amyloidosis is a transmissible process.