REPRESENTING SPATIAL INFORMATION FOR LIMB MOVEMENT - ROLE OF AREA 5 IN THE MONKEY
REPRESENTING SPATIAL INFORMATION FOR LIMB MOVEMENT - ROLE OF AREA 5 IN THE MONKEY
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DOI：
10.1093/cercor/5.5.391
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发表时间：
1995-09-01
期刊：
影响因子：
3.7
通讯作者：
CAMINITI, R
中科院分区：
文献类型：
--
作者：
LACQUANITI, F;GUIGON, E;CAMINITI, R
肢体运动的空间信息是如何在大脑中编码的？计算和心理物理研究表明，起始手的位置、通过点和目标是相对于身体指定的，以提供感觉(例如，动觉)再传入和产生肢体运动的命令之间的比较。这里我们认为顶上小叶(Brodmann区5)可能代表以身体为中心的位置编码的底物。在一项反应时间任务中，猴子在3D空间的不同部分做了手臂动作。我们发现，第5区神经元的活动可以与起点、终点DR或两者的组合有关。神经活动在以身体为中心的参照系中单调调节，参照系的坐标定义了手的方位、仰角和距离。每个空间坐标往往编码在不同的神经元亚群中。这种分离可能是心理物理学观察到的神经关联，在人类中，这些空间参数是平行处理的，并且在很大程度上相互独立。
How is spatial information for limb movement encoded in the brain? Computational and psychophysical studies suggest that beginning hand position, via-points, and target are specified relative to the body to afford a comparison between the sensory (e.g., kinesthetic) reafferences and the commands that generate limb movement. Here we propose that the superior parietal lobule (Brodmann area 5) might represent a substrate for a body-centered positional code. Monkeys made arm movements in different parts of 3D space in a reaction-time task. We found that the activity of area 5 neurons can be related to either the starting point, dr the final point, or combinations of the two. Neural activity is monotonically tuned in a body-centered frame of reference, whose coordinates define the azimuth, elevation, and distance of the hand. Each spatial coordinate tends to be encoded in a different sub population of neurons. This parcellation could be a neural correlate of the psychophysical observation that these spatial parameters are processed in parallel and largely independent of each other in man.