Molecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variation.
Molecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variation.
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尽管种族和地理存在差异，但慢性粒细胞白血病的分子病变是高度保守的。
作者：
Li Chong Chan;Po;R. Powles;E. Saragas;Leanne M. Wiedemann;J. Groffen;Mel Greaves
来自英国、台湾和南非的费城染色体阳性慢性粒细胞白血病患者的白血病细胞DNA，当用适当的DNA探针筛选时，不同种族的白血病细胞DNA在染色体22带q11上的断裂点簇区域都具有可识别的分子重排。这一结果加强了慢性粒细胞白血病分子损伤的高度保守性及其作为疾病诊断标志物的适用性。由于该检测可以通过对相对少量的非分裂冷冻或死细胞进行样品转介来进行，因此它非常适合大规模流行病学和临床研究，特别是在发展中国家，核型分析服务不容易获得。
Leukemic cell DNA from patients with Philadelphia chromosome positive chronic granulocytic leukemia in the United Kingdom, Taiwan, and South Africa and of diverse ethnic origins all have identifiable molecular rearrangements of the breakpoint cluster region on chromosome 22 band q11 when screened with an appropriate DNA probe. This result reinforces the highly conserved nature of the molecular lesion in chronic granulocytic leukemia and its suitability as a diagnostic marker for the disease. Since the assay can be performed by sample referral on relatively small numbers of nondividing frozen or dead cells, it is ideally suited for large scale epidemiological and clinical studies, particularly in developing countries where karyotyping services are not readily available.