Glycemic control and prognosis in type I diabetic patients with microalbuminuria
Glycemic control and prognosis in type I diabetic patients with microalbuminuria
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DOI：
10.2337/diacare.19.4.313
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发表时间：
1996-04-01
期刊：
影响因子：
16.2
通讯作者：
Ludvigsson, J
中科院分区：
文献类型：
--
作者：
Bojestig, M;Arnqvist, HJ;Ludvigsson, J
目的-调查过程中的微量白蛋白尿在20世纪80年代在I型糖尿病patients.Research设计和方法-这是一个为期10年的后续-在1961年至1980年期间15岁之前被诊断为I型糖尿病的109名患者中，1977年至1983年期间在糖尿病持续时间大于或等于3年微量白蛋白尿定义为三个连续尿液样本中的两个中的白蛋白排泄率（AER）为20-200 μ g/min。结果-在初步调查时，81名患者的AER正常，27名患者有微量白蛋白尿，1名患者有大量白蛋白尿。1989年至1992年，99例（91%）患者进行了重新调查。在10年随访期间，只有5例（19%）最初的微量白蛋白尿患者发生了大量蛋白尿，15例（58%）患者的AER降至正常。3例（4%）正常白蛋白尿患者出现微量白蛋白尿，但无大量蛋白尿。1980-1983年至1989-1991年，AER正常化的初始微量白蛋白尿患者血糖控制改善（平均值+/- SEHbA（1c）7.5 +/- 0.2至6.6 +/- 0.3%; P = 0.01）。结论：在大多数微量白蛋白尿患者中，微量白蛋白尿将消失，发生肾病的风险将显著降低。
OBJECTIVE - To investigate the course of microalbuminuria during the 1980s in type I diabetes patients.RESEARCH DESIGN AND METHODS - This was a 10-year follow-up of 109 patients in whom type I diabetes was diagnosed between 1961 and 1980 before 15 years of age and who were initially investigated between 1977 and 1983 after a diabetes duration of greater than or equal to 3 years. Microalbuminuria was defined as an albumin excretion rate (AER) of 20-200 mu g/min in two of three consecutive urine samples.RESULTS - At the initial investigation, 81 patients had normal AER, 27 had microalbuminuria, and 1 had macroalbuminuria. Between 1989 and 1992, 99 (91%) patients were reinvestigated. Only 5 (19%) of the initially microalbuminuric patients developed macroproteinuria during the 10-year follow-up period, and in 15 (58%) patients, AER decreased to normal. Three (4%) of the normoalbuminuric patients developed microalbuminuria but none macroproteinuria. The initially microalbuminuric patients, in whom AER normalized, improved their glycemic control from 1980-1983 to 1989-1991 (mean +/- SEHbA(1c) 7.5 +/- 0.2 to 6.6 +/- 0.3%; P = 0.01).CONCLUSIONS - In the majority of patients with microalbuminuria in whom it is possible to obtain good glycemic control, microalbuminuria will disappear and the risk of developing nephropathy will be markedly reduced.