Development of a hybrid microwave-optical tissue oxygenation probe to measure thermal response in the deep tissue.
Development of a hybrid microwave-optical tissue oxygenation probe to measure thermal response in the deep tissue.
复制标题
开发混合微波-光学组织氧合探头来测量深层组织的热响应。
DOI：
10.1007/978-1-4614-7411-1_49
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发表时间：
2013
影响因子：
--
通讯作者：
Al-Armaghany A
中科院分区：
文献类型：
--
作者：
Al-Armaghany A
设计了一种新型的无创微波-光学混合式组织氧合探头，该探头由微波生物相容性天线和光学探头组成。微波天线能够在深层组织中诱导局部热，从而引起组织血流并因此改变组织氧合。这些变化或热响应由光学探针使用近红外光谱法测量。热响应提供了人体组织中温度调节的重要信息。生物相容性天线的第一个原型被开发出来，并放置在人体小腿上进行体内实验。测量结果包括两名人类受试者的氧合血红蛋白、脱氧血红蛋白和总血红蛋白浓度变化（Δ HbO 2/ΔHHb/ΔHbT）、组织氧合指数和标准化组织血红蛋白指数。微波辐照5 min后，Δ HbO 2和ΔHbT均升高。受试者1（脂肪厚度= 6.8 mm）和受试者2（脂肪厚度= 5.0 mm）的热响应（定义为ΔHbT增加与持续时间的比值）分别为7.7 μM/s和18.9 μM/s，可能受脂肪厚度的影响。在这两名受试者中，微波天线关闭后，Δ HbO 2和ΔHbT继续增加约70 s。
The design of a new non-invasive hybrid microwave-optical tissue oxygenation probe is presented, which consists of a microwave biocompatible antenna and an optical probe. The microwave antenna is capable of inducing localised heat in the deep tissue, causing tissue blood flow and therefore tissue oxygenation to change. These changes or thermal responses are measured by the optical probe using near-infrared spectroscopy. Thermal responses provide important information on thermoregulation in human tissue. The first prototype of the biocompatible antenna was developed and placed on the human calf for in vivo experiments. The measured results include oxy-, deoxy- and total haemoglobin concentration changes (ΔHbO2/ΔHHb/ΔHbT), tissue oxygenation index and the normalised tissue haemoglobin index for two human subjects. Both ΔHbO2and ΔHbT show an increase during 5 min of microwave exposure. The thermal response, defined as the ratio of the increase in ΔHbT to the time duration, is 7.7 μM/s for subject 1 (fat thickness = 6.8 mm) and 18.9 μM/s for subject 2 (fat thickness = 5.0 mm), which may be influenced by the fat thicknesses. In both subjects, ΔHbO2and ΔHbT continued to increase for approximately another 70 s after the microwave antenna was switched off.
影响因子：
20.6
作者：
GUY, AW;LEHMANN, JF;STONEBRIDGE, JB
通讯作者：
STONEBRIDGE, JB
影响因子：
11.2
作者：
C. Song
通讯作者：
C. Song
影响因子：
6.7
作者：
Giombini, A.;Giovannini, V.;Maffulli, Nicola
通讯作者：
Maffulli, Nicola