Modified sham feeding of sweet solutions in women with anorexia nervosa
Modified sham feeding of sweet solutions in women with anorexia nervosa
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DOI：
10.1016/j.physbeh.2010.04.030
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发表时间：
2010-08-04
影响因子：
2.9
通讯作者：
Walsh, B. T.
中科院分区：
文献类型：
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作者：
Klein, D. A.;Schebendach, J. E.;Walsh, B. T.
神经性厌食症（AN）是一种自我饥饿的疾病，其特征是膳食量和食物摄入量减少。虽然AN的食物摄入减少可能反映了过量的抑制因子，例如，除了与害怕体重增加或异常摄食后负反馈有关的认知抑制外，摄入量减少也可能反映了食物摄入的口感觉刺激减少。这一直难以直接测试，因为AN患者在测试餐期间摄入的食物量反映了对进食的口感觉兴奋性、认知性、习得性和摄食后抑制性控制的整合。为了开始分离这些对照，我们采用改良的假喂养技术（MSF）来测量在没有摄食后刺激的情况下一系列甜味溶液的摄入量。AN受试者（n = 24）和正常对照组（NC，n = 10）被随机提供樱桃Kool Aid（R）溶液，该溶液在装有吸管的封闭不透明容器中加入5种浓度（0、0.01、0.03、0.08和0.28%）的甜化。他们被指示在15次1分钟的试验中尽可能多地啜饮溶液，并将液体吐入另一个不透明的容器中。AN受试者比NC受试者更少地啜饮无糖溶液（p
Anorexia Nervosa (AN) is a disorder of self-starvation characterized by decreased meal size and food intake. While it is possible that reduced food intake in AN reflects an excess of inhibitory factors, e.g., cognitive inhibition related to fear of weight gain or abnormal postingestive negative feedback, it is also possible that decreased intake reflects diminished orosensory stimulation of food intake. This has been difficult to test directly because the amount of food ingested during a test meal by patients with AN reflects an integration of orosensory excitatory, and cognitive, learned, and postingestive inhibitory controls of eating. To begin to dissociate these controls, we adapted the modified sham feeding technique (MSF) to measure the intake of a series of sweetened solutions in the absence of postingestive stimulation. Subjects with AN (n = 24) and normal controls (NC, n = 10) were randomly presented with cherry Kool Aid (R) solutions sweetened with five concentrations of aspartame (0, 0.01, 0.03, 0.08 and 0.28%) in a closed opaque container fitted with a straw. They were instructed to sip as much as they wanted of the solution during 15 1-minute trials and to spit the fluid out into another opaque container. Subjects with AN sipped less unsweetened solution than NC (p