Neurological basis of respiratory complications in achondroplasia
Neurological basis of respiratory complications in achondroplasia
复制标题
软骨发育不全呼吸并发症的神经学基础
作者：
F. Nelson;J. Hecht;W. Horton;I. Butler;W. Goldie;M. Miner
对32名软骨发育不全患者的评估显示，28%有呼吸暂停病史，22%在多导睡眠图上有呼吸异常。在那些需要后颅窝减压手术的患者中，随访多导睡眠图显示改善。多模态研究表明，脑干压迫在软骨发育不全中很常见，并且可以部分解释这种疾病中的呼吸功能异常，包括阻塞性呼吸暂停、中枢性呼吸暂停和低氧血症。
Evaluation of 32 individuals with achondroplasia revealed that 28% had a history of apnea and 22% had respiratory abnormalities on polysomnography. In those patients requiring posterior fossa Decemberompressive surgery, improvement was noted in follow‐up polysomnograms. Multimodality studies suggested that brainstem compression was common in achondroplasia and could account in part for the abnormal respiratory function in this disorder, including obstructive apnea, central apnea, and hypoxemia.
软骨发育不全的死亡率。
影响因子：
9.8
作者：
Hecht,JT;Francomano,CA;Horton,WA;Annegers,JF
通讯作者：
Annegers,JF