Mechanisms of ferroptosis and targeted therapeutic approaches in lymphoma.
Mechanisms of ferroptosis and targeted therapeutic approaches in lymphoma.
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DOI：
10.1038/s41419-023-06295-w
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发表时间：
2023-11-25
影响因子：
9
通讯作者：
Young, Ken H.
中科院分区：
文献类型：
--
作者：
Yu, Tiantian;Xu-Monette, Zijun Y.;Yu, Li;Li, Yong;Young, Ken H.
淋巴瘤是全球第六大常见癌症。在目前的治疗标准下，淋巴瘤患者往往治疗无效或早期复发，需要进一步治疗。因此，新的治疗策略需要探索，我们对淋巴瘤的分子基础的理解应该扩大。铁死亡是一种非凋亡调节的细胞死亡，其特征是由于代谢功能障碍导致活性氧和脂质过氧化增加。过度或缺乏铁下垂与肿瘤的发展有关。目前的临床前证据表明，铁下垂参与淋巴瘤的肿瘤发生、进展和耐药，确定了一个潜在的生物标志物和一个有吸引力的分子靶点。本文综述了铁下垂的核心机制和调控网络，并讨论了铁下垂诱导淋巴瘤治疗的现有证据，旨在为理解铁下垂在淋巴瘤发生中的作用提供一个框架，并为淋巴瘤治疗提供一个新的视角。
Lymphoma is the sixth most common type of cancer worldwide. Under the current treatment standards, patients with lymphoma often fail to respond to treatment or relapse early and require further therapy. Hence, novel therapeutic strategies need to be explored and our understanding of the molecular underpinnings of lymphomas should be expanded. Ferroptosis, a non-apoptotic regulated cell death, is characterized by increased reactive oxygen species and lipid peroxidation due to metabolic dysfunction. Excessive or lack of ferroptosis has been implicated in tumor development. Current preclinical evidences suggest that ferroptosis participates in tumorigenesis, progression, and drug resistance of lymphoma, identifying a potential biomarker and an attractive molecular target. Our review summarizes the core mechanisms and regulatory networks of ferroptosis and discusses existing evidences of ferroptosis induction for the treatment of lymphoma, with intent to provide a framework for understanding the role of ferroptosis in lymphomagenesis and a new perspective of lymphoma treatment.
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