Selective degradation of mitochondria by mitophagy
Selective degradation of mitochondria by mitophagy
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DOI：
10.1016/j.abb.2007.03.034
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发表时间：
2007-06-15
影响因子：
3.9
通讯作者：
Lemasters, John J.
中科院分区：
文献类型：
--
作者：
Kim, Insil;Rodriguez-Enriquez, Sara;Lemasters, John J.
线粒体是真核细胞产生有氧能量的重要场所。活性氧（ROS）是线粒体代谢过程中不可避免的副产物，可引起线粒体DNA突变和功能障碍。线粒体损伤也可能是疾病过程的结果。因此，维持健康的线粒体群体对细胞的健康至关重要。自噬传递到溶酶体是线粒体周转中的主要降解途径，我们使用术语线粒体自噬来指自噬引起的线粒体降解。虽然长期以来被认为是一个随机的过程，越来越多的证据表明，线粒体自噬是一个选择性的过程。本文综述了线粒体自噬的过程，线粒体通透性转换在线粒体自噬中的可能作用以及线粒体自噬在功能失调的线粒体周转中的重要性。(C)2007年爱思唯尔公司All rights reserved.
Mitochondria are the essential site of aerobic energy production in eukaryotic cells. Reactive oxygen species (ROS) are an inevitable by-product of mitochondrial metabolism and can cause mitochondrial DNA mutations and dysfunction. Mitochondrial damage can also be the consequence of disease processes. Therefore, maintaining a healthy population of mitochondria is essential to the well-being of cells. Autophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover, and we use the term mitophagy to refer to mitochondrial degradation by autophagy. Although long assumed to be a random process, increasing evidence indicates that mitophagy is a selective process. This review provides an overview of the process of mitophagy, the possible role of the mitochondrial permeability transition in mitophagy and the importance of mitophagy in turnover of dysfunctional mitochondria. (C) 2007 Elsevier Inc. All rights reserved.