Systemic lupus erythematosus with and without a family history: a meta-analysis
Systemic lupus erythematosus with and without a family history: a meta-analysis
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有或没有家族史的系统性红斑狼疮：荟萃分析
DOI：
10.1177/0961203317739133
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发表时间：
2018-04-01
期刊：
影响因子：
2.6
通讯作者：
Wang, L.
中科院分区：
文献类型：
--
作者：
Chen, L. Y.;Shi, Z. R.;Wang, L.
目的探讨家族性系统性红斑狼疮（SLE）与散发性SLE的临床表现及实验室指标的相关性。方法检索PubMed、EMBASE、Web of Science和中国知网（CNKI）数据库中的相关文献。这些研究的质量进行了评估，使用修订版的纽卡斯尔-渥太华量表。从每项研究中提取参与个体的特征和临床表现。使用随机效应方法计算合并比值比（OR），使用I2统计量量化研究间的异质性。结果在检索策略确定的330篇研究中，6篇被纳入本综述。其中家族性SLE 733例，散发性SLE 1405例。分析显示光敏性、肾炎和血小板减少与家族性SLE呈负相关，OR值（95% CI）分别为0.73（0.60-0.89）、0.72（0.59-0.88）和0.75（0.57-0.98）。结论光敏性、血小板减少和肾脏损害在非家族性SLE患者中可能更为常见，这一点有待于设计良好的大人群研究进一步证实。
Objective The objective of this paper is to investigate the association of clinical manifestations and laboratory parameters between familial systemic lupus erythematosus (SLE) and sporadic SLE. Methods All relevant literature was retrieved from the PubMed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) databases. The qualities of these studies were evaluated using a modified version of the Newcastle-Ottawa scale. The characteristics and clinical manifestations of involved individuals were extracted from each study. Pooled odds ratio (OR) was calculated using the random effects-method, and the heterogeneity between studies was quantified using the I2 statistic. Results Of 330 studies identified by the search strategy, six were included in this review. In total, 733 cases were familial SLE and 1405 were sporadic SLE. Analysis revealed that photosensitivity, nephritis and thrombocytopenia were negatively associated with familial SLE, with OR (95% CI) values of 0.73 (0.60–0.89), 0.72 (0.59–0.88) and 0.75 (0.57–0.98), respectively. Conclusions Photosensitivity, thrombocytopenia and renal involvement could be more common in non-familial SLE, which should be further confirmed by well-designed studies with large populations.