T-regulatory cells: are we re-discovering T suppressors?
T-regulatory cells: are we re-discovering T suppressors?
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DOI：
10.1016/s0165-2478(02)00182-7
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发表时间：
2002-12-03
影响因子：
4.4
通讯作者：
Vassiliadis, S
中科院分区：
文献类型：
--
作者：
Athanassakis, I;Vassiliadis, S
调节性T细胞被证明起源于胸腺，它们的作用是维持对胸腺内以及胸腺外自身抗原的自身耐受性。它们的作用模式，使用体内和体外系统，导致了不同的结论，需要细胞-细胞相互作用或调节抑制性细胞因子。我们对调节性T细胞的研究越多，我们就越能发现它与抑制性T细胞网络的旧概念的相似之处。在70年代和80年代早期，分子技术的知识有限，阻碍了研究人员进一步审查这个问题，而当时创造的术语T抑制剂和反抑制剂多年来已经被遗忘。现在是时候记住这些调查人员的工作，并尝试使用现有的知识和技术来解释他们的发现。(C)2002 Elsevier Science B. V.保留所有权利。
Regulatory T cells are shown to originate form the thymus and their role is to maintain self-tolerance to intra-thymic as well as extra-thymic self-antigens. Their mode of action, using in vivo and in vitro systems, has led to different conclusions as to the need of cell-cell interactions or regulation upon suppressive cytokines. The more we study regulatory T cells the more we find similarities to the old notion of the suppressor T cell network. The limited knowledge in molecular technology in the early 70s and 80s discouraged investigators to further scrutinize the issue and the terms T suppressors and contra-suppressors that were coined back then have been forgotten over the years. It is now time to remember the work of these investigators and attempt to explain their findings using the current knowledge and technology. (C) 2002 Elsevier Science B.V. All rights reserved.