TGF-beta and regulatory T cell in immunity and autoimmunity.
TGF-beta and regulatory T cell in immunity and autoimmunity.
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DOI：
10.1007/s10875-008-9251-y
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发表时间：
2008-11
影响因子：
9.1
通讯作者：
Flavell, Richard A.
中科院分区：
文献类型：
--
作者：
Wan, Yisong Y.;Flavell, Richard A.
The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-β). TGF-β and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis. The immune suppressive functions of TGF-β and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles for TGF-β and Treg cells in shaping the immune system and the inflammatory responses. In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms that underlie how these molecules control these responses.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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发表时间：
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影响因子：
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影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F